Zbtb16 - zinc finger and BTB domain containing 16 Gene

Also Known as Lx; Plzf; Zfp145; Znf145

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 353227

Summary

Enables several functions, including DNA-binding transcription factor activity; double-stranded DNA binding activity; and protein C-terminus binding activity. Involved in embryonic limb morphogenesis; ossification involved in bone maturation; and protein localization to nucleus. Located in cytosol; nucleus; and plasma membrane. Used to study caudal regression syndrome and polydactyly. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]

Zbtb16 Products (1)

mRNA Protein Name
NM_001013181.1 NP_001013199.1 zinc finger and BTB domain-containing protein 16

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14657020 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
14657020 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15925207 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19191224 RGD
enables type 2 angiotensin receptor binding IPI
IPI: Inferred from physical interaction
14657020 RGD
Biological Process GO Annotation Evidence References Source
involved in embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
19191224 RGD
involved in embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
19191224 RGD
involved in ossification involved in bone maturation IMP
IMP: Inferred from mutant phenotype
27727328 RGD
involved in protein localization to nucleus IDA
IDA: Inferred from direct assay
19191224 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 16

  • Polydactyly-luxate syndrome

  • promyelocytic leukemia zinc finger

  • zinc finger and BTB domain containing 16 protein

  • zinc finger protein 145

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153698 CC-3060 99.7% Unkown
HY-173614 CC-647 Modulator 99.58% Unkown
HY-RS15964 ZBTB16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18204 Zbtb16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24681 Zbtb16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Zbtb16 NCBI NCBI:7704