IL9R - interleukin 9 receptor Gene

Also Known as CD129; IL-9R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3581

About IL9R

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,997,696-156,013,020 (from NCBI)

This gene has 4 transcripts (splice variants), 172 orthologues and 7 paralogues. Biased expression in urinary bladder (RPKM 2.4), lymph node (RPKM 1.3) and 11 other tissues.

Summary

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

IL9R Products (2)

mRNA Protein Name
NM_002186.3 NP_002177.2 interleukin-9 receptor isoform 1 precursor
NM_176786.2 NP_789743.2 interleukin-9 receptor isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-9 receptor activity IDA
IDA: Inferred from direct assay
8193355 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-9-mediated signaling pathway IDA
IDA: Inferred from direct assay
8756628 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
18829468 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-9 receptor

  • IL-9 receptor

IL9R Antibodies

Cat. No. Product Name Application Reactivity
HY-P84457 CD129 Antibody (YA4154) WB, IHC-P, FC, ELISA Human, Rat
HY-P84457A CD129 Antibody (YA4154)(PBS only) WB, IHC-P, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Deafness, Y-Linked 2

  • DFNY2

  • Y-Linked Deafness 2
Bronchitis

  • Chronic Bronchitis

  • Acute Bronchitis

  • Bronchitis, Chronic

  • Acute Bronchitis And Bronchiolitis

  • Chest Cold

  • Chest Infection

  • Ci - Chest Infection

  • Recurrent Wheezy Bronchitis

  • Bronchitis Chronic

  • Lower Respiratory Tract Infection

  • Acute Lower Respiratory Tract Infection

  • Chronic Bronchitis Nos

  • Senile Bronchitis

  • Bronchitis Nos In Those Under L5 Years Of Age

  • Bronchitis Nos
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Mcd Diffuse Large B-Cell Lymphoma

  • Mcd Dlbcl

  • Doid:0081066
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06782 IL9R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174595 Human IL9R mRNA / Unkown
HY-RS18766 Il9r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25254 Il9r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus IL9R MGD MGI:96564
Rattus norvegicus IL9R RGD RGD:2907
Bos taurus IL9R VGNC VGNC:30172
Macaca mulatta IL9R VGNC VGNC:81422
Felis catus IL9R VGNC VGNC:67788
Others IL9R NCBI