Ptprf - protein tyrosine phosphatase, receptor type, F Gene

Also Known as LARFN5C

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360406

Summary

Enables phosphate ion binding activity; signaling receptor binding activity; and transmembrane receptor protein tyrosine Phosphatase activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of signal transduction; and regulation of cell projection organization. Located in several cellular components, including excitatory synapse; growth cone; and neuronal cell body. Is integral component of postsynaptic density membrane. Biomarker of obesity. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine Phosphatase receptor type F). [provided by Alliance of Genome Resources, Apr 2022]

Ptprf Products (1)

mRNA Protein Name
NM_019249.2 NP_062122.2 receptor-type tyrosine-protein phosphatase F precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin receptor binding IDA
IDA: Inferred from direct assay
7711057 RGD
enables phosphate ion binding IDA
IDA: Inferred from direct assay
1918076 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12629171 RGD
enables protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
8068021 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16415345 RGD
enables transmembrane receptor protein tyrosine phosphatase activity IDA
IDA: Inferred from direct assay
7711057 RGD
Biological Process GO Annotation Evidence References Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12716943 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16415345 RGD
involved in negative regulation of cell projection organization IMP
IMP: Inferred from mutant phenotype
10699984 RGD
involved in negative regulation of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
16415345 RGD
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8557682 RGD
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
8557682 RGD
involved in negative regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10699984 RGD
involved in nervous system development IDA
IDA: Inferred from direct assay
12716943 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9501065 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
15750591 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10699984 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
7711057 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
15750591 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
15750591 RGD
involved in regulation of synapse structure or activity IMP
IMP: Inferred from mutant phenotype
15750591 RGD
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
20139422 RGD
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
20139422 RGD
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
16269466 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
15750591 RGD
located in growth cone IDA
IDA: Inferred from direct assay
9604206 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9748473 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
15750591 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase F

  • LAR

  • leukocyte antigen-related (LAR) PTP receptor

  • leukocyte common antigen related

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11438 PTPRF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17614 Ptprf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24074 Ptprf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprf NCBI NCBI:5792