OGDH - Ogdh oxoglutarate dehydrogenase Gene

Also Known as E1o; OGDH-E1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360975

Summary

Enables chaperone binding activity; heat shock protein binding activity; and oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in several processes, including 2-oxoglutarate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Part of oxoglutarate dehydrogenase complex. Orthologous to human OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

OGDH Products (1)

mRNA Protein Name
NM_001017461.1 NP_001017461.1 2-oxoglutarate dehydrogenase complex component E1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
9811814 RGD
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IDA
IDA: Inferred from direct assay
9712727 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
9811814 RGD
Biological Process GO Annotation Evidence References Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
3571202 RGD
involved in NADH metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in succinyl-CoA metabolic process IDA
IDA: Inferred from direct assay
9712727 RGD
involved in tricarboxylic acid cycle IDA
IDA: Inferred from direct assay
9712727 RGD
Cellular Component GO Annotation Evidence References Source
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
3571202 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

2-oxoglutarate dehydrogenase complex component E1

2-oxoglutarate dehydrogenase, mitochondrial

  • 2-oxoglutarate dehydrogenase E1 component, mitochondrial

  • 2-oxoglutarate dehydrogenase, mitochondrial-like

  • OGDC-E1

  • alpha-KGDH-E1

  • alpha-ketoglutarate dehydrogenase

  • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

  • oxoglutarate dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12688A Succinyl phosphonate trisodium salt Inhibitor 98.0% Unkown
HY-RS17494 Ogdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09758 OGDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23951 Ogdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens OGDH NCBI NCBI:4967