UBE3A - Ube3a ubiquitin protein ligase E3A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 361585

Summary

Predicted to enable transcription coactivator activity and ubiquitin protein Ligase activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; locomotory exploration behavior; and motor learning. Predicted to be located in cytosol and nucleus. Predicted to be part of Proteasome complex. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein Ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]

UBE3A Products (1)

mRNA Protein Name
NM_001191837.4 NP_001178766.1 ubiquitin-protein ligase E3A

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
25867122 RGD
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
32066685 RGD
involved in motor learning IMP
IMP: Inferred from mutant phenotype
32066685 RGD
involved in negative regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25867122 RGD
involved in positive regulation of Golgi lumen acidification IMP
IMP: Inferred from mutant phenotype
23447592 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
24810662 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17883392 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-protein ligase E3A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-177615 Apazunersen Inhibitor / Phase 3
HY-177615A Apazunersen sodium Inhibitor / Phase 3
HY-177651 Obudanersen Inhibitor / Phase 2
HY-177651A Obudanersen sodium Inhibitor / Phase 2
HY-148130 Rugonersen Activator 98.50% Phase 1
HY-148130A Rugonersen sodium 97.47% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162683 (S)-PHA533533 98.27% Unkown
HY-RS15368 UBE3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20508 Ube3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27016 Ube3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens UBE3A NCBI NCBI:7337