PNPLA2 - patatin-like phospholipase domain containing 2 Gene

Rattus norvegicus

Also known as RGD1309044

Gene ID: 361676 | Gene type: protein coding

About PNPLA2

Primary_assembly 1: 196,552,723-196,557,805 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 193 orthologues, 4 paralogues and is associated with 11 phenotypes. Biased expression in Thymus (RPKM 668.7), Adrenal (RPKM 61.7) and 9 other tissues.

Summary

Predicted to enable retinyl-palmitate esterase activity and triglyceride Lipase activity. Predicted to be involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Predicted to act upstream of or within cellular lipid catabolic process and lipid droplet organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm; lipid droplet; and membrane. Orthologous to human PNPLA2 (patatin like Phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

PNPLA2 Products(1)

mRNA	Protein	Name
NM_001108509.2	NP_001101979.2	patatin-like phospholipase domain-containing protein 2

PNPLA2 Protein Structure

Pat_PNPLA2

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

patatin-like phospholipase domain-containing protein 2

adipose triglyceride lipase	calcium-independent phospholipase A2-zeta
iPLA2-zeta	patatin-like phospholipase domain-containing protein 2-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS10791	PNPLA2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS10792	Pnpla2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS10793	PNPLA2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PNPLA2	NCBI	NCBI:57104

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