Lrp8 - LDL receptor related protein 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362558

Summary

Enables high-density lipoprotein particle binding activity and Kinesin binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to growth factor stimulus; and cerebral cortex development. Located in several cellular components, including dendrite; neuronal cell body; and postsynaptic density. Part of microtubule associated complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Lrp8 Products (20)

mRNA Protein Name
XM_039111159.1 XP_038967087.1 low-density lipoprotein receptor-related protein 8 isoform X18
XM_006238570.3 XP_006238632.1 low-density lipoprotein receptor-related protein 8 isoform X1
XM_039111149.1 XP_038967077.1 low-density lipoprotein receptor-related protein 8 isoform X3
XM_039111148.1 XP_038967076.1 low-density lipoprotein receptor-related protein 8 isoform X2
XM_006238567.3 XP_006238629.1 low-density lipoprotein receptor-related protein 8 isoform X9
XM_039111152.1 XP_038967080.1 low-density lipoprotein receptor-related protein 8 isoform X7
XM_006238571.3 XP_006238633.1 low-density lipoprotein receptor-related protein 8 isoform X4
XM_039111150.1 XP_038967078.1 low-density lipoprotein receptor-related protein 8 isoform X5
XM_039111151.1 XP_038967079.1 low-density lipoprotein receptor-related protein 8 isoform X6
XM_003749993.4 XP_003750041.1 low-density lipoprotein receptor-related protein 8 isoform X8
XM_039111153.1 XP_038967081.1 low-density lipoprotein receptor-related protein 8 isoform X10
XM_003749992.4 XP_003750040.1 low-density lipoprotein receptor-related protein 8 isoform X11
XM_039111154.1 XP_038967082.1 low-density lipoprotein receptor-related protein 8 isoform X12
XM_039111155.1 XP_038967083.1 low-density lipoprotein receptor-related protein 8 isoform X13
XM_342877.8 XP_342878.5 low-density lipoprotein receptor-related protein 8 isoform X14
XM_039111157.1 XP_038967085.1 low-density lipoprotein receptor-related protein 8 isoform X16
XM_039111158.1 XP_038967086.1 low-density lipoprotein receptor-related protein 8 isoform X17
XM_039111156.1 XP_038967084.1 low-density lipoprotein receptor-related protein 8 isoform X15
XM_006238574.3 XP_006238636.1 low-density lipoprotein receptor-related protein 8 isoform X20
XM_039111160.1 XP_038967088.1 low-density lipoprotein receptor-related protein 8 isoform X19

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables high-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
2993274 RGD
enables kinesin binding IPI
IPI: Inferred from physical interaction
11238452 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cholesterol IEP
IEP: Inferred from expression pattern
19414061 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
8626535 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
20368265 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20368265 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
10867025 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9822699 RGD
part of microtubule associated complex IDA
IDA: Inferred from direct assay
11238452 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10867025 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 8

  • low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07802 LRP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19912 Lrp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26413 Lrp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp8 NCBI NCBI:7804