GALNT18 - polypeptide N-acetylgalactosaminyltransferase 18 Gene

Also Known as GALNT15; GALNTL4; GALNACT18; GalNAc-T15; GalNAc-T18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374378

About GALNT18

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:11,270,877-11,622,005 (from NCBI)

This gene has 2 transcripts (splice variants), 289 orthologues and 19 paralogues. Broad expression in thyroid (RPKM 3.7), lung (RPKM 3.5) and 24 other tissues.

Summary

Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

GALNT18 Products (2)

mRNA Protein Name
NM_001363464.2 NP_001350393.1 polypeptide N-acetylgalactosaminyltransferase 18 isoform 2
NM_198516.3 NP_940918.2 polypeptide N-acetylgalactosaminyltransferase 18 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
22186971 GOA
Biological Process GO Annotation Evidence References Source
involved in protein O-linked glycosylation IDA
IDA: Inferred from direct assay
22186971 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALNT18 Protein Structure

Glycos_transf_2

Glycos_transf_2: Glycosyl transferase family 2 (157 - 294)

Ricin_B_lectin

Ricin_B_lectin: Ricin-type beta-trefoil lectin domain (470 - 594)

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  • 607 a.a.
Protein Preferred Names Protein Names

polypeptide N-acetylgalactosaminyltransferase 18

  • GalNAc-transferase 18

Related Diseases

Diseases Alias
Okur-Chung Neurodevelopmental Syndrome

  • OCNDS

  • Csnk2a1-Related Neurodevelopmental Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05255 GALNT18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GALNT18 MGD MGI:2446239
Canis familiaris GALNT18 VGNC VGNC:41093
Felis catus GALNT18 VGNC VGNC:103031
Bos taurus GALNT18 VGNC VGNC:29230
Macaca mulatta GALNT18 VGNC VGNC:72811
Rattus norvegicus GALNT18 RGD RGD:1309623
Others GALNT18 NCBI