KCND1 - potassium voltage-gated channel subfamily D member 1 Gene

Also Known as KV4.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3750

About KCND1

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,961,380-48,971,844 (from NCBI)

This gene has 3 transcripts (splice variants), 85 orthologues and 31 paralogues. Ubiquitous expression in gall bladder (RPKM 1.4), brain (RPKM 1.1) and 24 other tissues.

Summary

This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type Potassium Channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, Insulin secretion, and smooth muscle contraction. [provided by RefSeq, Aug 2013]

KCND1 Products (1)

mRNA Protein Name
NM_004979.6 NP_004970.3 potassium voltage-gated channel subfamily D member 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables A-type (transient outward) potassium channel activity IDA
IDA: Inferred from direct assay
15454437 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCND1 Protein Structure

Shal-type

Shal-type: Shal-type voltage-gated potassium channels, N-terminal (3 - 31)

BTB_2

BTB_2: BTB/POZ domain (43 - 131)

Ion_trans

Ion_trans: Ion transport protein (233 - 407)

DUF3399

DUF3399: Domain of unknown function (DUF3399) (447 - 550)

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  • 647 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily D member 1

  • Shal-type potassium channel

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07112 KCND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCND1 RGD RGD:621364
Macaca mulatta KCND1 VGNC VGNC:73975
Felis catus KCND1 VGNC VGNC:67901
Mus musculus KCND1 MGD MGI:96671
Bos taurus KCND1 VGNC VGNC:30434
Canis familiaris KCND1 VGNC VGNC:42239
Others KCND1 NCBI