KCNG1 - potassium voltage-gated channel modifier subfamily G member 1 Gene

Also Known as K13; kH2; KCNG; KV6.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3755

About KCNG1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:51,003,656-51,023,107 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 31 paralogues. Biased expression in endometrium (RPKM 3.9), placenta (RPKM 2.0) and 11 other tissues.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This gene is abundantly expressed in skeletal muscle. Multiple alternatively spliced transcript variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

KCNG1 Products (1)

mRNA Protein Name
NM_002237.4 NP_002228.2 potassium voltage-gated channel subfamily G member 1
Molecular Function GO Annotation Evidence References Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
19074135 GOA
Cellular Component GO Annotation Evidence References Source
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
19074135 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNG1 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (65 - 164)

Ion_trans

Ion_trans: Ion transport protein (270 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily G member 1

  • potassium channel KH2

Related Diseases

Diseases Alias
Coumarin Resistance
  • Warfarin Resistance

  • Warfarin Sensitivity

  • Coumadin Sensitivity

  • Warfarin Response

  • Poor Metabolism Of Coumarin

  • Coumarin, Poor Metabolism Of

  • CMRES

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus KCNG1 VGNC VGNC:30442
Mus musculus KCNG1 MGD MGI:3616086
Rattus norvegicus KCNG1 RGD RGD:631416
Macaca mulatta KCNG1 VGNC VGNC:73979
Canis familiaris KCNG1 VGNC VGNC:42245
Felis catus KCNG1 VGNC VGNC:67906