ENTPD8 - ectonucleoside triphosphate diphosphohydrolase 8 Gene

Also Known as UNQ2492; GLSR2492; E-NTPDase; NTPDase-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 377841

About ENTPD8

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,434,364-137,441,357 (from NCBI)

This gene has 4 transcripts (splice variants), 171 orthologues and 7 paralogues. Biased expression in colon (RPKM 14.4), duodenum (RPKM 11.4) and 6 other tissues.

Summary

Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside diphosphate biosynthetic process and nucleoside monophosphate biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ENTPD8 Products (2)

mRNA Protein Name
NM_001033113.2 NP_001028285.1 ectonucleoside triphosphate diphosphohydrolase 8 isoform 1
NM_198585.3 NP_940987.2 ectonucleoside triphosphate diphosphohydrolase 8 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD8 Protein Structure

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (38 - 454)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

ectonucleoside triphosphate diphosphohydrolase 8

  • E-NTPDase 8

Related Diseases

Diseases Alias
Spastic Paraplegia 64, Autosomal Recessive

  • SPG64

  • Hereditary Spastic Paraplegia 64

  • Autosomal Recessive Spastic Paraplegia Type 64

  • Autosomal Recessive Spastic Paraplegia 64

  • Paraplegia, Spastic, Type 64, Autosomal Recessive
Vasculogenic Impotence

  • Impotence, Vasculogenic
Trichomoniasis

  • Trichomonas Infection

  • Trichomonas Infections

  • Disease Due To Trichomonadidae

  • Infection By Trichomonas

  • Trichomonadosis

  • Trichomonas Pruritus

  • Trichomonosis

  • Tricomoniasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04401 ENTPD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18988 Cant1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ENTPD8 VGNC VGNC:28513
Mus musculus ENTPD8 MGD MGI:1919340
Canis familiaris ENTPD8 VGNC VGNC:40386
Felis catus ENTPD8 VGNC VGNC:61884
Macaca mulatta ENTPD8 VGNC VGNC:72104
Rattus norvegicus ENTPD8 RGD RGD:1561793
Others ENTPD8 NCBI