KCNS1 - potassium voltage-gated channel modifier subfamily S member 1 Gene

Also Known as Kv9.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3787

About KCNS1

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,091,214-45,101,127 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.8), gall bladder (RPKM 1.3) and 3 other tissues.

Summary

Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly Other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the Potassium Channel family. [provided by RefSeq, Jul 2008]

KCNS1 Products (2)

mRNA Protein Name
NM_001322799.2 NP_001309728.1 potassium voltage-gated channel subfamily S member 1
NM_002251.5 NP_002242.2 potassium voltage-gated channel subfamily S member 1
Molecular Function GO Annotation Evidence References Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
10484328 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10484328 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
10484328 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10484328 GOA
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10484328 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNS1 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (52 - 151)

Ion_trans

Ion_trans: Ion transport protein (275 - 456)

  • 0
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  • 200
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  • 500
  • 526 a.a.
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily S member 1

  • delayed-rectifier K(+) channel alpha subunit 1

Related Diseases

Diseases Alias
Causalgia
  • Complex Regional Pain Syndrome, Type Ii

  • Complex Regional Pain Syndrome Type 2

Paroxysmal Extreme Pain Disorder
  • PEPD

  • Familial Rectal Pain

  • Pexpd

  • Submandibular, Ocular, And Rectal Pain With Flushing

  • Pain, Submandibular, Ocular, And Rectal, With Flushing

  • Rectal Pain, Familial

  • Submandibular, Ocular And Rectal Pain With Flushing

  • Familial Rectal Syndrome

  • Frp

  • Pain Disorder, Paroxysmal, Extreme

Erythromelalgia
  • Primary Erythromelalgia

  • Erythermalgia

  • Primary Erythermalgia

  • Mitchell Disease

  • Familial Erythromelalgia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus KCNS1 VGNC VGNC:30491
Mus musculus KCNS1 MGD MGI:1197019
Rattus norvegicus KCNS1 RGD RGD:621524
Felis catus KCNS1 VGNC VGNC:67932
Canis familiaris KCNS1 VGNC VGNC:42293
Macaca mulatta KCNS1 VGNC VGNC:84919
Others KCNS1 NCBI