KCNS1 - potassium voltage-gated channel modifier subfamily S member 1 Gene
Also Known as Kv9.1
Species: Homo sapiens
About KCNS1
This gene has 2 transcripts (splice variants), 187 orthologues and 31 paralogues. Biased expression in brain (RPKM 2.8), gall bladder (RPKM 1.3) and 3 other tissues.
Summary
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly Other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the Potassium Channel family. [provided by RefSeq, Jul 2008]
KCNS1 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001322799.2 | NP_001309728.1 | potassium voltage-gated channel subfamily S member 1 |
| NM_002251.5 | NP_002242.2 | potassium voltage-gated channel subfamily S member 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables potassium channel regulator activity |
IDA
IDA: Inferred from direct assay
|
10484328 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10484328 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in regulation of potassium ion transmembrane transport |
IDA
IDA: Inferred from direct assay
|
10484328 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
10484328 | GOA |
| part of voltage-gated potassium channel complex |
IDA
IDA: Inferred from direct assay
|
10484328 | GOA |
KCNS1 Protein Structure
BTB_2: BTB/POZ domain (52 - 151)
Ion_trans: Ion transport protein (275 - 456)
- 0
- 100
- 200
- 300
- 400
- 500
- 526 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
potassium voltage-gated channel subfamily S member 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Causalgia |
|
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| Paroxysmal Extreme Pain Disorder |
|
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| Erythromelalgia |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | KCNS1 | VGNC | VGNC:30491 |
| Mus musculus | KCNS1 | MGD | MGI:1197019 |
| Rattus norvegicus | KCNS1 | RGD | RGD:621524 |
| Felis catus | KCNS1 | VGNC | VGNC:67932 |
| Canis familiaris | KCNS1 | VGNC | VGNC:42293 |
| Macaca mulatta | KCNS1 | VGNC | VGNC:84919 |
| Others | KCNS1 | NCBI |