Lemd3 - LEM domain containing 3 Gene

Also Known as Man1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 380664

Summary

Predicted to enable chromatin DNA binding activity. Acts upstream of or within several processes, including blood vessel endothelial cell migration involved in intussusceptive angiogenesis; regulation of extracellular matrix organization; and skeletal muscle cell differentiation. Located in nuclear envelope. Is expressed in several structures, including allantois; foregut diverticulum endoderm; lateral plate mesoderm; neural plate; and primitive streak. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome. Orthologous to human LEMD3 (LEM domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Lemd3 Products (1)

mRNA Protein Name
NM_001081193.2 NP_001074662.2 inner nuclear membrane protein Man1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
16943282 MGI
acts upstream of or within blood vessel endothelial cell migration involved in intussusceptive angiogenesis IMP
IMP: Inferred from mutant phenotype
16943282 MGI
acts upstream of or within nucleus organization IMP
IMP: Inferred from mutant phenotype
16943282 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19720741 MGI
acts upstream of or within regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
16943282 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19720741 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
10671519 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inner nuclear membrane protein Man1

  • LEM domain-containing protein 3

  • integral inner nuclear membrane protein MAN1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07589 LEMD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22607 Lemd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29122 Lemd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lemd3 NCBI NCBI:23592