Atp2b4 - ATPase, Ca++ transporting, plasma membrane 4 Gene

Also Known as Pmca4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 381290

Summary

Enables scaffold protein binding activity and Sodium Channel regulator activity. Involved in several processes, including negative regulation of blood vessel endothelial cell migration; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of cardiac muscle hypertrophy in response to stress. Located in T-tubule and sperm flagellum. Part of protein-containing complex. Is expressed in several structures, including bladder; heart; intestine wall; liver; and nervous system. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b4 Products (2)

mRNA Protein Name
NM_001167949.2 NP_001161421.1 plasma membrane calcium-transporting ATPase 4 isoform a
NM_213616.4 NP_998781.1 plasma membrane calcium-transporting ATPase 4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28827723 MGI
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
18591664 MGI
enables sodium channel regulator activity IMP
IMP: Inferred from mutant phenotype
18591664 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to acetylcholine IMP
IMP: Inferred from mutant phenotype
16956963 MGI
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
15078889 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
15078889 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
25147342 MGI
involved in negative regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
25147342 MGI
involved in negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
25147342 MGI
involved in negative regulation of cardiac muscle hypertrophy in response to stress IMP
IMP: Inferred from mutant phenotype
19287093 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25147342 MGI
involved in urinary bladder smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16956963 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
19287093 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
18591664 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
19287093 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
15078889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plasma membrane calcium-transporting ATPase 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01197 ATP2B4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20525 Atp2b4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27034 Atp2b4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2b4 NCBI NCBI:493