SHISA2 - shisa family member 2 Gene

Also Known as TMEM46; hShisa; C13orf13; PRO28631; WGAR9166; bA398O19.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 387914

About SHISA2

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,044,597-26,052,016 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 5 paralogues. Biased expression in thyroid (RPKM 17.4), lung (RPKM 4.1) and 3 other tissues.

Summary

Predicted to be involved in negative regulation of Wnt signaling pathway and negative regulation of Fibroblast Growth Factor receptor signaling pathway. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

SHISA2 Products (1)

mRNA	Protein	Name
NM_001007538.2	NP_001007539.1	protein shisa-2 homolog precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHISA2 Protein Structure

Shisa

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
protein shisa-2 homolog	shisa homolog 2

Related Diseases

Diseases	Alias
Breast Medullary Carcinoma	Medullary Breast Carcinoma Medullary Breast Carcinoma With Lymphoid Stroma Medullary Carcinoma Of Breast
Mirror Movements 1	Congenital Mirror Movement Disorder Bimanual Synergia Congenital Mirror Movements Familial Congenital Controlateral Synkinesia Familial Congenital Mirror Movements Hereditary Congenital Controlateral Synkinesia Hereditary Congenital Mirror Movements Isolated Congenital Controlateral Synkinesia Isolated Congenital Mirror Movements Mirror Movements MRMV1 Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum Mirror Movements, Congenital Bimanual Synkinesis Cmm Mirror Movements, Type 1
Nephronophthisis 11	NPHP11 Nephronophthisis, Type 11

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12866	SHISA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SHISA2	MGD	MGI:2444716
Felis catus	SHISA2	VGNC	VGNC:102318
Rattus norvegicus	SHISA2	RGD	RGD:1561256
Macaca mulatta	SHISA2	VGNC	VGNC:106294
Bos taurus	SHISA2	VGNC	VGNC:34598
Others	SHISA2	NCBI