LDLR - low density lipoprotein receptor Gene

Also Known as FH; FHC; FHCL1; LDLCQ2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3949

About LDLR

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,089,463-11,133,820 (from NCBI)

This gene has 14 transcripts (splice variants), 129 orthologues, 14 paralogues and is associated with 4 phenotypes. Ubiquitous expression in adrenal (RPKM 29.0), lung (RPKM 28.5) and 25 other tissues.

Summary

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/Cholesterol and is taken into the cell. Lysosomes release the Cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in Cholesterol synthesis. At the same time, a reciprocal stimulation of Cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]

LDLR Products (6)

mRNA	Protein	Name
NM_000527.5	NP_000518.1	low-density lipoprotein receptor isoform 1 precursor
NM_001195798.2	NP_001182727.1	low-density lipoprotein receptor isoform 2 precursor
NM_001195799.2	NP_001182728.1	low-density lipoprotein receptor isoform 3 precursor
NM_001195800.2	NP_001182729.1	low-density lipoprotein receptor isoform 4 precursor
NM_001195803.2	NP_001182732.1	low-density lipoprotein receptor isoform 6 precursor
NM_001406861.1	NP_001393790.1	low-density lipoprotein receptor isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26526611	GOA
enables low-density lipoprotein particle binding	IMP IMP: Inferred from mutant phenotype	6299582	GOA
enables low-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	6091915	GOA
enables low-density lipoprotein particle receptor activity	IMP IMP: Inferred from mutant phenotype	6299582	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	22091758	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	22081141	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10571240	GOA
enables very-low-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	8626535	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	6299582	GOA
involved in cholesterol homeostasis	IGI IGI: Inferred from genetic interaction	24412220	GOA
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	6299582	GOA
involved in cholesterol import	IMP IMP: Inferred from mutant phenotype	6299582	GOA
involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	17142622	GOA
involved in intestinal cholesterol absorption	IMP IMP: Inferred from mutant phenotype	17142622	GOA
involved in long-term memory	IGI IGI: Inferred from genetic interaction	24412220	GOA
involved in low-density lipoprotein particle clearance	IMP IMP: Inferred from mutant phenotype	6299582	GOA
involved in negative regulation of low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	17452316	GOA
involved in negative regulation of receptor recycling	IDA IDA: Inferred from direct assay	17452316	GOA
involved in receptor-mediated endocytosis involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	6299582	GOA
involved in regulation of protein metabolic process	IGI IGI: Inferred from genetic interaction	24412220	GOA
involved in response to caloric restriction	IGI IGI: Inferred from genetic interaction	24412220	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	17461796	GOA
part of PCSK9-LDLR complex	IDA IDA: Inferred from direct assay	22081141	GOA
part of PCSK9-LDLR complex	IPI IPI: Inferred from physical interaction	22081141	GOA
located in cell surface	IDA IDA: Inferred from direct assay	17461796	GOA
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	6091915	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15166224	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15166224	GOA
located in late endosome	IDA IDA: Inferred from direct assay	17461796	GOA
located in lysosome	IDA IDA: Inferred from direct assay	15166224	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDLR Protein Structure

Ldl_recept_a

FXa_inhibition

EGF_CA

Ldl_recept_b

FXa_inhibition

0
200
400
600
800
860 a.a.

Protein Preferred Names	Protein Names
low-density lipoprotein receptor	LDL receptor

LDLR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LDLR	P01130	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	LDLR	P01130	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	LDLR	P01130	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	LDLR	P01130	APOE	Homo sapiens	P02649	NMR	24447298
Intra	LDLR	P01130	APOE	Homo sapiens	P02649	NMR	20030366
Intra	LDLR	P01130	APOE	Homo sapiens	P02649	SPR	24447298
Intra	LDLR	P01130	PCSK9	Homo sapiens	Q8NBP7-1	GMS	18753623
Intra	LDLR	P01130	PCSK9	Homo sapiens	Q8NBP7-1	Anti Bait CoIP	18753623
Intra	LDLR	P01130	APOH	Homo sapiens	P02749	Fluorescence Spectr	20223219
Intra	LDLR	P01130	APOH	Homo sapiens	P02749	FPS	20223219
Intra	LDLR	P01130	APOH	Homo sapiens	P02749	NMR	20223219
Intra	LDLR	P01130	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	LDLR	P01130	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	LDLR	P01130	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	LDLR	P01130	APOB	Homo sapiens	P04114	NMR	24447298
Intra	LDLR	P01130	LRPAP1	Homo sapiens	P30533	NMR	20030366
Intra	LDLR	P01130	PCSK9	Homo sapiens	Q8NBP7	SPR	22081141
Intra	LDLR	P01130	PCSK9	Homo sapiens	Q8NBP7	X-Ray Diffraction	22081141
Intra	LDLR	P01130	PCSK9	Homo sapiens	Q8NBP7	BN-PAGE	25613181

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LDLR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70235	LDLR Protein, Human (HEK293, His)	P01130-1 (A22-R788)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72392	LDLR Protein, Human (Biotinylated, HEK293, Avi-His)	P01130-1 (A22-R788)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700860	LDLR Protein, Human (HEK293, Avi-His)	P01130-1 (A22-R788)	≥ 95%, as determined by reducing SDS-PAGE.

LDLR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83717	LDLR Antibody (YA3452)	WB, IHC-P	Human, Mouse

Related Diseases

Diseases	Alias
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Homozygous Familial Hypercholesterolemia	Hofh
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Carotid Artery Occlusion	Occlusion And Stenosis Of Carotid Artery
Carotid Artery Dissection	Dissection Of Carotid Artery
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Coronary Heart Disease 5	Coronary Heart Disease, Susceptibility To, 5 CHDS5 Coronary Artery Disease, Early-Onset Coronary Artery Disease Early-Onset Early-Onset Coronary Artery Disease Heart, Coronary, Disease, Susceptibility To, Type 5
Hyperlipoproteinemia, Type Iii	Hyperlipoproteinemia Type Iii Broad-Betalipoproteinemia Floating-Betalipoproteinemia Familial Type 3 Hyperlipoproteinemia Broad Beta Disease Familial Hyperbeta- And Prebetalipoproteinemia Familial Hypercholesterolemia With Hyperlipemia Hyperlipemia With Familial Hypercholesterolemic Xanthomatosis Coronary Artery Disease, Severe, Susceptibility To Coronary Artery Disease, Severe Hyperlipidemia Type 3 Familial Dysbetalipoproteinemia Hyperlipoproteinemia Type 3 Coronary Artery Disease Apolipoprotein E, Deficiency Or Defect Of Dysbetalipoproteinemia Due To Defect In Apolipoprotein E-D Carbohydrate Induced Hyperlipemia Familial Hypercholesterolaemia With Hyperlipaemia Remnant Hyperlipidemia Remnant Removal Disease Dysbetalipoproteinemia Broad-Beta Disease Familial Dyslipidemia Type 3 Hlp Type 3 Remnant Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iii CAD Hyperlipoproteinemia 3 HLPP3 Deficiency Or Defect Of Apolipoprotein E Dysbetalipoproteinemia Due To Defect In Apolipoprotein E Coronary Arteriosclerosis Coronary Heart Disease
Aortic Dissection
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Stomatitis
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Hypercholesterolemia, Familial, 2	Hypercholesterolemia, Autosomal Dominant, Type B FHCL2 Apolipoprotein B-100, Familial Defective Apolipoprotein B-100, Familial Ligand-Defective Hypercholesterolemia, Familial, Due To Ligand-Defective Apolipoprotein B Autosomal Dominant Type B Hypercholesterolemia Familial Ligand-Defective Apolipoprotein B-100 Fdb Hypercholesterolemia, Familial, Type 2 Hyperlipoproteinemia Type Iib
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Autosomal Recessive Arh FHCL4 Autosomal Recessive Hypercholesterolemia Arh1 Arh2 Autosomal Recessive Hypercholesterolemia 1 Autosomal Recessive Hypercholesterolemia 2 Fhcb1 Fhcb2 Hypercholesterolemia, Autosomal Recessive, 1, Formerly Arh1, Formerly Fhcb1, Formerly Hypercholesterolemia, Autosomal Recessive, 2, Formerly Arh2, Formerly Fhcb2, Formerly Familial Autosomal Recessive Hypercholesterolemia Hypercholesterolemia, Familial, Autosomal Recessive Hypercholesterolemia, Familial, Type 4
Arcus Corneae	Arcus Senilis Corneal Arcus Arcus Of Cornea
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Smith-Lemli-Opitz Syndrome	SLOS Rsh Syndrome 7-Dehydrocholesterol Reductase Deficiency Slo Syndrome Rutledge Lethal Multiple Congenital Anomaly Syndrome Lethal Acrodysgenital Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung Smith-Opitz-Inborn Syndrome Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung Smith Lemli Opitz Syndrome Smith-Lemli-Opitz Syndrome, Type Ii
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Hypoalphalipoproteinemia
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Hepatoblastoma
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14668	Lomitapide mesylate	Inhibitor	99.61%	Yes
HY-B0374A	Moxonidine hydrochloride		99.83%	Unkown
HY-B0374	Moxonidine		99.72%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3
HY-124560	Lifibrol		/	Phase 3
HY-152857	Muvalaplin	Inhibitor	99.96%	Phase 2
HY-18778	Obicetrapib	Inhibitor	99.93%	Phase 2
HY-109567	Gemcabene	Inhibitor	99.91%	Phase 2
HY-109567A	Gemcabene calcium	Inhibitor	98.0%	Phase 2
HY-116175	BIBB 515		99.56%	Phase 1
HY-172661	Kylo-0603	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99793	Orticumab	Inhibitor	≥99.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-NP013	Oxidized low density lipoprotein (mouse)		98.00%	Unkown
HY-P2341	Angiopep-2 hydrochloride		99.61%	Unkown
HY-N0466	Rebaudioside A	Activator	98.0%	Unkown
HY-145001	20-HC-Me-Pyrrolidine	Inhibitor	99.69%	Unkown
HY-W007347	1,2-Cyclohexanedione		98.68%	Unkown
HY-W015600	2-Acetamidophenol	Inhibitor	99.73%	Unkown
HY-101529	Imanixil		99.29%	Unkown
HY-N0627	Kaempferol-7-O-β-D-glucopyranoside		99.79%	Unkown
HY-N0430A	Coptisine Sulfate		99.37%	Unkown
HY-158424	LSN3353871	Inhibitor	99.62%	Unkown
HY-W018587	TBPH		95.0%	Unkown
HY-P10502A	L57 acetate		99.01%	Unkown
HY-125544	LY 295427	Modulator	98.0%	Unkown
HY-W015600S	2-Acetamidophenol-d3		99.48%	Unkown
HY-142026	Vitisin A	Inhibitor	96%	Unkown
HY-120651	LDL-IN-2	Inhibitor	99.0%	Unkown
HY-P10502	L57		99.44%	Unkown
HY-P10697A	VH4127 TFA	Modulator	/	Unkown
HY-P11452A	(KKEEE)3K acetate		98.13%	Unkown
HY-100144	Pirozadil		98.31%	Unkown
HY-181997	LDLRAP1-IN-1	Inhibitor	/	Unkown
HY-W423578	LDLR regulator-1	Modulator	99.89%	Unkown
HY-101812	Terbufibrol		98.39%	Unkown
HY-A0127	Etofibrate	Activator	99.80%	Unkown
HY-N0430	Coptisine		/	Unkown
HY-130587	Sultosilic acid piperazine salt		/	Unkown
HY-U00054	LDL-IN-3	Inhibitor	/	Unkown
HY-159595	PCSK9-IN-29	Inducer	99.44%	Unkown
HY-138089	17β-Hydroxy exemestane	Inhibitor	98.21%	Unkown
HY-178335	SGC-CK1γ-1	Inhibitor	99.33%	Unkown
HY-176274	FASN/SCD-IN-1	Inhibitor	/	Unkown
HY-P11071	PCSK9 Inhibitor, EGF-A	Degrader	/	Unkown
HY-167870	Piceatannol 4'-O-glucoside	Inhibitor	/	Unkown
HY-P10911	IETP2	Ligand	/	Unkown
HY-167873	Habenariol	Inhibitor	/	Unkown
HY-113288	Campestanol	Inhibitor	99.0%	Unkown
HY-105961	F 2833	Inhibitor	/	Unkown
HY-115914	Lipid-lowering agent-1		/	Unkown
HY-147279	Milpocitide		/	Unkown
HY-P10698	VH-N412		/	Unkown
HY-P11452	(KKEEE)3K		/	Unkown
HY-177291	LAB687	Inhibitor	/	Unkown
HY-P10697	VH4127	Modulator	/	Unkown
HY-179459	SJ-300	Inhibitor	/	Unkown
HY-N15706	Luteolin-7-O-β-D-glucuronide methyl ester		/	Unkown
HY-B0374AS	Moxonidine-13C,d3 hydrochloride		/	Unkown
HY-172699	DSPE-PEG2000-ANG		/	Unkown
HY-18778B	Obicetrapib potassium	Inhibitor	/	Unkown
HY-P10697B	H-PEG6-VH4127-NH2		/	Unkown
HY-161941	MeIm		/	Unkown
HY-B0374S1	Moxonidine-d7		/	Unkown
HY-18778A	Obicetrapib sodium	Inhibitor	/	Unkown
HY-126551	Butenoyl-PAF		/	Unkown
HY-B0374S2	Moxonidine-d3		/	Unkown
HY-18778C	Obicetrapib hemicalcium	Activator	/	Unkown
HY-161938	BRD8518		/	Unkown
HY-28911	2-Hydroxyacetaldehyde	Modulator	/	Unkown
HY-123260	S12340	Inhibitor	/	Unkown
HY-165512	Nicanartine	Inhibitor	99.36%	Unkown
HY-B0374S	Moxonidine-d4		/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990202	Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4)	Inhibitor	98.10%	Unkown
HY-P99505	Ziltivekimab		99.75%	Unkown
HY-P990143	Anti-Mouse/Rat/Bovine VLDL-R Antibody (IgG-6A6)	Inhibitor	95.00%	Unkown
HY-P990480	Anti-oxLDL Antibody		96.99%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LDLR	VGNC	VGNC:42622
Macaca mulatta	LDLR	VGNC	VGNC:74248
Felis catus	LDLR	VGNC	VGNC:68031
Bos taurus	LDLR	VGNC	VGNC:55214
Mus musculus	LDLR	MGD	MGI:96765
Rattus norvegicus	LDLR	RGD	RGD:2998
Others	LDLR	NCBI