PRSS57 - serine protease 57 Gene

Also Known as NSP4; PRSSL1; UNQ782

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 400668

About PRSS57

This gene has 2 transcripts (splice variants), 114 orthologues and 14 paralogues. Restricted expression toward bone marrow (RPKM 54.0).

Summary

This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]

PRSS57 Products (2)

mRNA	Protein	Name
NM_001308209.2	NP_001295138.2	serine protease 57 isoform 2 precursor
NM_214710.5	NP_999875.2	serine protease 57 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heparin binding	IDA IDA: Inferred from direct assay	25156428	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	25156428	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	22474388	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in azurophil granule lumen	IDA IDA: Inferred from direct assay	23904161	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	22474388	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRSS57 Protein Structure

Trypsin

0
100
200
283 a.a.

Protein Preferred Names	Protein Names
serine protease 57	neutrophil serine protease 4

Related Diseases

Diseases	Alias
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus
Osmotic Diarrhea
Acute Diarrhea
Secretory Diarrhea
Venezuelan Equine Encephalitis	Venezuelan Equine Fever Venezuelan Equine Encephalomyelitis Encephalitis Venezuelan Equine Encephalomyelitis, Venezuelan Equine Venezuelan Encephalitis Disorder Due To Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Virus Infection Venezuelan Equine Encephalomyelitis Virus Disease
Papillon-Lefevre Syndrome	Papillon-Lefevre Disease Papillon-Lefèvre Syndrome PLS Keratosis Palmoplantaris With Periodontopathia PALS Papillon Lefevre Syndrome Keratosis Palmoplantar-Periodontopathy Syndrome Papillon-Lefvre Syndrome Hyperkeratosis Palmoplantaris With Periodontosis Keratoris Palmoplantaris With Periodontopathia Keratosis Palmoplantar - Periodontopathy Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction Palmoplantar Keratoderma With Periodontosis Palsy
Noonan Syndrome 4	NS4 Noonan Syndrome, Type 4
Griscelli Syndrome, Type 3	Griscelli Syndrome Type 3 GS3 Griscelli-Prunieras Syndrome Type 3 Hypomelanosis With No Immunologic Or Neurologic Manifestations Griscelli Syndrome 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11258	PRSS57 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21915	Prss57 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PRSS57	VGNC	VGNC:64403
Bos taurus	PRSS57	VGNC	VGNC:33425
Macaca mulatta	PRSS57	VGNC	VGNC:76352
Rattus norvegicus	PRSS57	RGD	RGD:1303330
Canis familiaris	PRSS57	VGNC	VGNC:54343
Mus musculus	PRSS57	MGD	MGI:1920356
Others	PRSS57	NCBI