YY2 - YY2 transcription factor Gene

Also Known as ZNF631

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 404281

About YY2

Cytogenetic location: Xp22.12 Genomic coordinates (GRCh38): X:21,855,987-21,858,740 (from NCBI)

This gene has 1 transcript (splice variant), 21 orthologues and 2 paralogues.

Summary

The protein encoded by this gene is a transcription factor that includes several Kruppel-like zinc fingers in its C-terminal region. It possesses both activation and repression domains, and it can therefore have both positive and negative effects on the transcription of target genes. This gene has an intronless coding region, and it appears to have arisen by retrotransposition of the related YY1 transcription factor gene, which is located on chromosome 14. [provided by RefSeq, May 2010]

YY2 Products (1)

mRNA Protein Name
NM_206923.4 NP_996806.2 transcription factor YY2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15087442 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16260628 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15087442 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16260628 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16260628 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YY2 Protein Structure

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (255 - 278)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (298 - 323)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (327 - 353)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

transcription factor YY2

  • transcription factor yin yang 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1321 GR231118 Antagonist / Unkown
HY-RS15948 YY2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22089 Yy2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28609 Yy2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YY2 MGD MGI:3837947
Rattus norvegicus YY2 RGD RGD:2324567