Notch4 - notch receptor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 406162

Summary

Predicted to enable Notch binding activity. Involved in endothelial cell morphogenesis and wound healing. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (Notch receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Notch4 Products (1)

mRNA Protein Name
NM_001002827.1 NP_001002827.1 neurogenic locus notch homolog protein 4 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in endothelial cell differentiation IDA
IDA: Inferred from direct assay
10964583 RGD
involved in endothelial cell morphogenesis IDA
IDA: Inferred from direct assay
10964583 RGD
involved in luteolysis IEP
IEP: Inferred from expression pattern
21209419 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenic locus notch homolog protein 4

  • notch 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15670 BMS-906024 Inhibitor 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09452 NOTCH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18097 Notch4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24571 Notch4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990177 Anti-Mouse Notch4 Antibody (HMN4-14) Inhibitor / Unkown
HY-P992279 Anti-Notch4 Antibody / Unkown
HY-P990252 Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Notch4 NCBI NCBI:4855