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MAGOH - mago homolog, exon junction complex subunit Gene

Also Known as MAGOH1; MAGOHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4116

About MAGOH

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,226,900-53,238,518 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 28.8), colon (RPKM 24.3) and 25 other tissues.

Summary

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

MAGOH Products (1)

mRNA	Protein	Name
NM_002370.4	NP_002361.1	protein mago nashi homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10662555	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI IGI: Inferred from genetic interaction	23917022	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	16209946	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	22203037	GOA
involved in regulation of mRNA processing	IDA IDA: Inferred from direct assay	23115303	GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	19478851	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16601204	GOA
part of exon-exon junction complex	IPI IPI: Inferred from physical interaction	16931718	GOA
part of exon-exon junction subcomplex mago-y14	IPI IPI: Inferred from physical interaction	12781131	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGOH Protein Structure

Mago_nashi

0
100
146 a.a.

Protein Preferred Names	Protein Names
protein mago nashi homolog	mago homolog, exon junction complex core component

MAGOH Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Validated Y2H	32296183
Intra	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Y2H Array	32296183
Intra	MAGOH	P61326	DPH2	Homo sapiens	Q9BQC3	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	32296183
Intra	MAGOH	P61326	PPP1R16B	Homo sapiens	Q96T49	Y2H Array	32296183
Intra	MAGOH	P61326	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	FXR1	Homo sapiens	P51114-2	Y2H Array	32296183
Intra	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7-2	TAP	18066079
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	33961781
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	TAP	18066079
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	16209946
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	19478851
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Bait CoIP	19410547
Intra	MAGOH	P61326	PYM1	Homo sapiens	Q9BRP8	Anti Tag CoIP	23084401
Intra	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Validated Y2H	32296183
Intra	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Y2H Array	32296183
Intra	MAGOH	P61326	ZKSCAN8	Homo sapiens	Q15776	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	14730019
Intra	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	TAP	18066079
Intra	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Bait CoIP	19410547
Intra	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	TAP	16170325
Intra	MAGOH	P61326	EIF4A3	Homo sapiens	P38919	Anti Tag CoIP	16209946
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	16209946
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	Pull Down	14973490
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	19478851
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	TAP	18066079
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	TAP	16170325
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Bait CoIP	19410547
Intra	MAGOH	P61326	CASC3	Homo sapiens	O15234	Anti Tag CoIP	23084401
Intra	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	19478851
Intra	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Bait CoIP	19410547
Intra	MAGOH	P61326	UPF3B	Homo sapiens	Q9BZI7	Anti Tag CoIP	16209946
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H	22365833
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Bait CoIP	19410547
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	16209946
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Lumier	29997244
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	14730019
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	19410547
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Array	32296183
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	BRET	29997244
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Validated Y2H	25416956
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Validated Y2H	32296183
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	33961781
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H	10662555
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	12730685
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Lumier	32814053
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Y2H Prey Pooling	25416956
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Anti Tag CoIP	23084401
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9	Pull Down	10662555
Intra	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	MAGOH	P61326	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	TAP	18066079
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	TAP	16170325
Intra	MAGOH	P61326	RBM8A	Homo sapiens	Q9Y5S9-1	Anti Tag CoIP	19478851
Intra	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
Intra	MAGOH	P61326	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	MAGOH	P61326	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	MAGOH	P61326	TADA2A	Homo sapiens	O75478	Validated Y2H	25416956
Intra	MAGOH	P61326	IPO13	Homo sapiens	O94829	Pull Down	21139563

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAGOH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76484	MAGOH Protein, Human (His)	P61326-1/NP_002361.1 (M1-I146)	≥ 90%, as determined by reducing SDS-PAGE.

MAGOH Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82824	MAGOH Antibody (YA2569)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Metaphyseal Chondrodysplasia, Schmid Type	MCDS Schmid Metaphyseal Chondrodysplasia Metaphyseal Chondrodysplasia Schmid Type Spondylometaphyseal Dysplasia, Japanese Type Japanese Type Spondylometaphyseal Dysplasia Schmid Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia Type Schmid Schmid Type Metaphyseal Chondrodysplasia SMCD Chondrodysplasia, Metaphyseal, Schmid Type Corneal Dystrophy, Subepithelial Mucinous
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07986	MAGOHB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07985	MAGOH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20985	Magoh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27502	Magoh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAGOH	VGNC	VGNC:107580
Rattus norvegicus	MAGOH	RGD	RGD:1305174
Mus musculus	MAGOH	MGD	MGI:1330312
Others	MAGOH	NCBI