2. Gene
  3. MAX - MYC associated factor X Gene

MAX - MYC associated factor X Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as bHLHd4

Gene ID: 4149 | Gene type: protein coding

About MAX

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,006,101-65,102,695 (from NCBI)

This gene has 20 transcripts (splice variants), 283 orthologues and is associated with 89 phenotypes. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and Apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MAX Products(29)

mRNA Protein Name
NM_001271068.2 NP_001257997.1 protein max isoform g
NM_001271069.2 NP_001257998.1 protein max isoform h
NM_001320415.2 NP_001307344.1 protein max isoform i
NM_001407094.1 NP_001394023.1 protein max isoform a
NM_001407095.1 NP_001394024.1 protein max isoform b
NM_001407096.1 NP_001394025.1 protein max isoform j
NM_001407097.1 NP_001394026.1 protein max isoform j
NM_001407098.1 NP_001394027.1 protein max isoform k
NM_001407099.1 NP_001394028.1 protein max isoform l
NM_001407100.1 NP_001394029.1 protein max isoform l
NM_001407101.1 NP_001394030.1 protein max isoform l
NM_001407102.1 NP_001394031.1 protein max isoform l
NM_001407103.1 NP_001394032.1 protein max isoform c
NM_001407104.1 NP_001394033.1 protein max isoform c
NM_001407105.1 NP_001394034.1 protein max isoform i
NM_001407106.1 NP_001394035.1 protein max isoform i
NM_001407107.1 NP_001394036.1 protein max isoform i
NM_001407108.1 NP_001394037.1 protein max isoform m
NM_001407109.1 NP_001394038.1 protein max isoform m
NM_001407110.1 NP_001394039.1 protein max isoform m
NM_001407111.1 NP_001394040.1 protein max isoform n
NM_001407112.1 NP_001394041.1 protein max isoform n
NM_001407113.1 NP_001394042.1 protein max isoform g
NM_001407114.1 NP_001394043.1 protein max isoform o
NM_002382.5 NP_002373.3 protein max isoform a
NM_145112.3 NP_660087.1 protein max isoform b
NM_145113.3 NP_660088.1 protein max isoform c
NM_145114.3 NP_660089.1 protein max isoform d
NM_197957.4 NP_932061.1 protein max isoform f

MAX Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (24 - 74)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

protein max

class D basic helix-loop-helix protein 4

Recombinant MAX Proteins

Cat. No. Product Name Accession Purity
HY-P70388 MAX Protein, Human (His) P61244-2 (M1-S151) ≥95%
HY-P73832 MAX Protein, Human (sf9, His-GST) P61244 (M1-S160) ≥95%

Related Diseases

Diseases Alias
Hereditary Paraganglioma-Pheochromocytoma Syndromes

Hereditary Pheochromocytoma-Paraganglioma

Hereditary Paraganglioma-Pheochromocytoma

Familial Pheochromocytoma-Paraganglioma

Paragangliomas 2

Paragangliomas 3

Paragangliomas 4

Sdhx-Related Paraganglioma-Pheochromocytoma

Familial Paraganglioma Syndrome

Familial Paraganglioma-Pheochromocytoma Syndromes

Fpgl

Fpgl/Pheo

Paragangliomas 1

Paraganglioma
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Bap1 Tumor Predisposition Syndrome

Bap1-Related Tumor Predisposition Syndrome

Common Syndrome

Bap1 Cancer Syndrome

Bap1-Tpds

Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms

Tumor Predisposition Syndrome

Tumor Susceptibility Linked To Germline Bap1 Mutations

Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms

Tumor Predisposition
Inherited Cancer-Predisposing Syndrome

Hereditary Cancer-Predisposing Syndrome
Paraganglioma

Chemodectoma

Glomus Body Tumor

Paragangliomas

Carotid Body Paraganglioma

Extra-Adrenal Paraganglioma
Spastic Paraplegia 84, Autosomal Recessive

SPG84

Hereditary Spastic Paraplegia 84

Spastic Paraplegia 84 Autosomal Recessive

Doid:0112347
Spastic Paraplegia 85, Autosomal Recessive

SPG85

Hereditary Spastic Paraplegia 85

Spastic Paraplegia 85 Autosomal Recessive

Doid:0112345
Spastic Paraplegia 86, Autosomal Recessive

SPG86

Hereditary Spastic Paraplegia 86

Spastic Paraplegia 86 Autosomal Recessive

Doid:0112342
Esophagus Leiomyoma

Leiomyoma Of Esophagus
Persistent Generalized Lymphadenopathy

Pgl

Persistant Generalized Lymphadenopathy
Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a

Sipple Syndrome

Multiple Endocrine Neoplasia Type 2

MEN2A

Men2

Ptc Syndrome

Multiple Endocrine Neoplasia, Type 2

Multiple Endocrine Neoplasia Iia

Men 2a

Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma

Multiple Endocrine Neoplasia, Type 2a

Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma

Multiple Endocrine Neoplasia Ii

Men2 Syndrome

Men-2a Syndrome

Multiple Neoplasia 2a

Multiple Neoplasia Type 2
Duodenal Somatostatinoma

Duodenal Delta Cell Somatostatin Producing Tumor

Duodenal Somatostatin-Producing Neuroendocrine Tumor
Sweeney-Cox Syndrome

SWCOS
Malignant Pheochromocytoma

Pheochromocytoma, Malignant
Adrenal Medulla Cancer

Adrenal Medulla Neoplasm

Adrenal Medulla Tumor

Malignant Neoplasm Of Adrenal Medulla

Malignant Tumor Of The Adrenal Medulla

Adrenal Medulla Carcinoma

Neoplasm Of Adrenal Medulla
Peripheral Nervous System Benign Neoplasm
Autonomic Nervous System Benign Neoplasm
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Paraganglioma And Gastric Stromal Sarcoma

Carney-Stratakis Syndrome

Paraganglioma And Gastrointestinal Stromal Tumor

Carney Dyad

Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma

Paraganglioma And Gist

Carney-Stratakis Dyad

Gist-Paraganglioma Dyad

PGGSS

Paraganglioma, Gastric Stromal Sarcoma

Gastrointestinal Stromal Tumors
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws
Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12702 10058-F4 Inhibitor 99.77% Unkown
HY-135969 Glycol chitosan Inhibitor 61.22% Unkown
HY-124675 MYCMI-6 98.14% Unkown
HY-100669 Mycro 3 Inhibitor 99.21% Unkown
HY-100996 10074-G5 Inhibitor 98.52% Unkown
HY-122683 sAJM589 Inhibitor 99.65% Unkown
HY-12703 KSI-3716 Inhibitor 99.76% Unkown
HY-144878 VPC-70619 Inhibitor ≥99.0% Unkown
HY-145723 MAX-40279 Inhibitor 97.10% Unkown
HY-134975 NY2267 Inhibitor 99.34% Unkown
HY-153064 MAX-10181 Inhibitor 98.07% Unkown
HY-131021 Janelia Fluor® 549, Azide / Unkown
HY-N5072 Desmethylglycitein Inhibitor 98.98% Unkown
HY-137551 Tiafenacil Inhibitor 99.20% Unkown
HY-N6878 Cauloside D 99.69% Unkown
HY-N7273 Soyasaponin III Inducer 99.73% Unkown
HY-130736 Janelia Fluor® 549, SE / Unkown
HY-131022 Janelia Fluor® 549 TFA 96.56% Unkown
HY-N6919 Cauloside C Inhibitor 99.66% Unkown
HY-145723A MAX-40279 hydrochloride Inhibitor / Unkown
HY-145723B MAX-40279 hemifumarate Inhibitor 99.56% Unkown
HY-145723C MAX-40279 hemiadipate Inhibitor 99.26% Unkown
HY-125636 Mycro1 / Unkown
HY-125978 JY-3-094 Inhibitor / Unkown
HY-126979 Mycro2 / Unkown
HY-131023 Janelia Fluor® 549, Maleimide TFA / Unkown
HY-131024 Janelia Fluor® 549, Tetrazine / Unkown
HY-133536 PA Janelia Fluor® 549, SE / Unkown
HY-147291 VPC-70063 / Unkown
HY-150259 MDEG-541 Degrader / Unkown
HY-N1228 Soyacerebroside I / Unkown
HY-N6999 Soyasaponin Ac / Unkown
HY-RS08177 MAX Human Pre-designed siRNA Set A / Unkown
HY-115839A Detajmium L-tartrate / Unkown
HY-N12273 Soyasaponin Ae / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAX VGNC VGNC:74667
Rattus norvegicus MAX RGD RGD:621101
Felis catus MAX VGNC VGNC:80920
Canis familiaris MAX VGNC VGNC:43045
Mus musculus MAX MGD MGI:96921
Bos taurus MAX VGNC VGNC:31269
Others MAX NCBI