ADAM11 - ADAM metallopeptidase domain 11 Gene

Also Known as MDC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4185

About ADAM11

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,758,988-44,781,846 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues and 20 paralogues. Biased expression in brain (RPKM 9.4), heart (RPKM 3.1) and 5 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast Cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

ADAM11 Products (2)

mRNA Protein Name
NM_001318933.2 NP_001305862.1 disintegrin and metalloproteinase domain-containing protein 11 isoform 3
NM_002390.6 NP_002381.2 disintegrin and metalloproteinase domain-containing protein 11 isoform 1 preproprotein

ADAM11 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (46 - 189)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (239 - 438)

Disintegrin

Disintegrin: Disintegrin (453 - 528)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (531 - 645)

  • 0
  • 200
  • 400
  • 600
  • 769 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 11

  • ADAM 11

Related Diseases

Diseases Alias
Epilepsy, Familial Temporal Lobe, 1

  • ETL1

  • Adpeaf

  • Adlte

  • Epilepsy, Partial, With Auditory Features

  • Autosomal Dominant Partial Epilepsy With Auditory Features

  • Epilepsy, Lateral Temporal Lobe, Autosomal Dominant

  • Familial Temporal Lobe Epilepsy 1

  • Partial Epilepsy With Auditory Features

  • Autosomal Dominant Lateral Temporal Lobe Epilepsy

  • Lateral Temporal Lobe Epilepsy Autosomal Dominant

  • Epilepsy, Temporal Lobe, Familial, Type 1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00268 ADAM11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19048 Adam11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25538 Adam11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAM11 VGNC VGNC:37573
Macaca mulatta ADAM11 VGNC VGNC:69466
Rattus norvegicus ADAM11 RGD RGD:1307515
Bos taurus ADAM11 VGNC VGNC:55768
Mus musculus ADAM11 MGD MGI:1098667
Felis catus ADAM11 VGNC VGNC:59574
Others ADAM11 NCBI