Adcy1 - adenylate cyclase 1 Gene

Also Known as AC1; brl; I-AC; D11Bwg1392e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 432530

Summary

Enables Adenylate Cyclase activity. Involved in several processes, including modulation of chemical synaptic transmission; neuroinflammatory response; and positive regulation of CREB transcription factor activity. Acts upstream of or within axonogenesis and long-term memory. Located in cytoplasm; glutamatergic synapse; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (Adenylate Cyclase 1). [provided by Alliance of Genome Resources, Apr 2022]

Adcy1 Products (1)

mRNA	Protein	Name
NM_009622.2	NP_033752.1	adenylate cyclase type 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenylate cyclase activity	IGI IGI: Inferred from genetic interaction	10482244	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	17229090	MGI
acts upstream of or within long-term memory	IGI IGI: Inferred from genetic interaction	10482244	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	10482244	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10482244	MGI
involved in neuroinflammatory response	IMP IMP: Inferred from mutant phenotype	12441059	MGI
involved in positive regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	12441059	MGI
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	10482244	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	9547227	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	9547227	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	24048828	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	10482244	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	10482244	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	24482543	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	9547227	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	9547227	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	9547227	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	9547227	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	18448650	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	17335981	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	17335981	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
adenylate cyclase type 1	ATP pyrophosphate-lyase 1 Ca(2+)/calmodulin-activated adenylyl cyclase adenylate cyclase type I adenylyl cyclase 1 barrelless

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00326	ADCY1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21473	Adcy1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27991	Adcy1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adcy1	NCBI	NCBI:107