Otulin - OTU deubiquitinase with linear linkage specificity Gene

Also Known as m3Sapc; Fam105b; m7-1Sapc

Species: Mus musculus

Gene Type: protein coding
Gene ID: 432940

Summary

Enables thiol-dependent Deubiquitinase. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU Deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Apr 2022]

Otulin Products (1)

mRNA Protein Name
NM_001013792.2 NP_001013814.2 ubiquitin thioesterase otulin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23708998 MGI
enables cysteine-type peptidase activity IMP
IMP: Inferred from mutant phenotype
23708998 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
27523608 MGI
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
27523608 MGI
involved in protein linear deubiquitination IDA
IDA: Inferred from direct assay
23708998 MGI
involved in regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
23708998 MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
27523608 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
23708998 MGI
Cellular Component GO Annotation Evidence References Source
part of LUBAC complex IDA
IDA: Inferred from direct assay
23708998 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
23708998 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin thioesterase otulin

  • OTU domain-containing deubiquitinase with linear linkage specificity

  • deubiquitinating enzyme otulin

  • family with sequence similarity 105, member B

  • gumby

  • protein FAM105B

  • ubiquitin thioesterase Gumby

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19070 Otulin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09878 OTULIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25560 Otulin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Otulin NCBI NCBI:90268