THBS1 - Thbs1 thrombospondin 1 Gene

Also Known as Tsp1; TSP-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 445442

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of transforming growth factor beta production; and response to testosterone. Located in cytoplasm and extracellular space. Biomarker of diabetic retinopathy; heart disease; myocardial infarction; and prostate Cancer. Human ortholog(s) of this gene implicated in cholangiocarcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human THBS1 (thrombospondin 1). [provided by Alliance of Genome Resources, Apr 2022]

THBS1 Products (2)

mRNA Protein Name
NM_001013062.3 NP_001013080.2 thrombospondin-1 isoform 1 precursor
NM_001398940.1 NP_001385869.1 thrombospondin-1 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
10487979 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
15831915 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
15831915 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
18772338 RGD
involved in positive regulation of transforming growth factor beta production IMP
IMP: Inferred from mutant phenotype
17640965 RGD
involved in response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
18772338 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
15665307 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16754856 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thrombospondin-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14479 THBS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16903 Thbs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23345 Thbs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens THBS1 NCBI NCBI:7057