NDUFB4 - NADH:ubiquinone oxidoreductase subunit B4 Gene

Also Known as B15; CI-B15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4710

About NDUFB4

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:120,596,336-120,602,507 (from NCBI)

This gene has 6 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in adrenal (RPKM 52.4), heart (RPKM 52.2) and 25 other tissues.

Summary

This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

NDUFB4 Products (2)

mRNA Protein Name
NM_001168331.2 NP_001161803.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2
NM_004547.6 NP_004538.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB4 Protein Structure

NDUF_B4

NDUF_B4: NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) (5 - 129)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

  • NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

NDUFB4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81593 NDUFB4 Antibody (YA1338) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat
HY-P81593A NDUFB4 Antibody (YA1338)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Polyomavirus-Associated Nephropathy

  • Polyomavirus Associated Nephropathy

  • Pvan
Latex Allergy
Hantavirus Hemorrhagic Fever With Renal Syndrome

  • Hemorrhagic Fever, Russian

  • Hemorrhagic Nephrosonephritis

  • Hfrs

  • Puumala Virus Nephropathy

  • Hemorrhagic Fever With Renal Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09149 NDUFB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21894 Ndufb4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28411 Ndufb4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NDUFB4 RGD RGD:1307072
Felis catus NDUFB4 VGNC VGNC:102785
Canis familiaris NDUFB4 VGNC VGNC:43703
Mus musculus NDUFB4 MGD MGI:1915444
Macaca mulatta NDUFB4 VGNC VGNC:75157
Others NDUFB4 NCBI