Cntnap2 - contactin associated protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500105

Summary

Enables protease binding activity and transmembrane transporter binding activity. Involved in prepulse inhibition. Located in several cellular components, including main axon; neuronal cell body; and synaptic membrane. Used to study autism spectrum disorder and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cntnap2 Products (5)

mRNA Protein Name
XM_039109025.1 XP_038964953.1 contactin-associated protein-like 2 isoform X1
XM_039109028.1 XP_038964956.1 contactin-associated protein-like 2 isoform X3
XM_039109027.1 XP_038964955.1 contactin-associated protein-like 2 isoform X3
XM_039109026.1 XP_038964954.1 contactin-associated protein-like 2 isoform X2
XM_039109029.1 XP_038964957.1 contactin-associated protein-like 2 isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IPI
IPI: Inferred from physical interaction
19166515 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
10624965 RGD
Biological Process GO Annotation Evidence References Source
involved in prepulse inhibition IMP
IMP: Inferred from mutant phenotype
30126973 RGD
involved in startle response IMP
IMP: Inferred from mutant phenotype
30126973 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
26217189 RGD
located in axolemma IDA
IDA: Inferred from direct assay
10624965 RGD
located in dendrite IDA
IDA: Inferred from direct assay
10624965 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26217189 RGD
located in juxtaparanode region of axon IDA
IDA: Inferred from direct assay
10624965 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10624965 RGD
located in paranode region of axon IDA
IDA: Inferred from direct assay
10624965 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
26217189 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
18179895 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

contactin-associated protein-like 2

  • contactin associated protein-like 2

  • mKIAA0868 protein-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02933 CNTNAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19088 Cntnap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25578 Cntnap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntnap2 NCBI NCBI:26047