Tpm2 - tropomyosin 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 500450

Summary

Enables actin filament binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in actin filament organization; muscle contraction; and regulation of ATPase activity. Located in actin Cytoskeleton. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1A and nemaline myopathy 4. Orthologous to human TPM2 (tropomyosin 2). [provided by Alliance of Genome Resources, Apr 2022]

Tpm2 Products (2)

mRNA Protein Name
NM_001024345.2 NP_001019516.1 tropomyosin beta chain isoform Tpm2.1sm/cy
NM_001301235.1 NP_001288164.1 tropomyosin beta chain isoform Tpm2.2st

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
7568216 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7568216 RGD
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
7568216 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
7568216 RGD
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
7568216 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin beta chain

  • beta-tropomyosin

  • tropomyosin 2, beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS18641 Tpm2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14937 TPM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25126 Tpm2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm2 NCBI NCBI:7169