P2RX5 - purinergic receptor P2X 5 Gene

Also Known as P2X5; LRH-1; P2X5R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5026

About P2RX5

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,673,227-3,696,155 (from NCBI)

This gene has 12 transcripts (splice variants), 252 orthologues and 6 paralogues. Biased expression in lymph node (RPKM 41.6), spleen (RPKM 36.1) and 4 other tissues.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]

P2RX5 Products (4)

mRNA Protein Name
NM_001204519.2 NP_001191448.1 P2X purinoceptor 5 isoform D
NM_001204520.2 NP_001191449.1 P2X purinoceptor 5 isoform E
NM_002561.4 NP_002552.2 P2X purinoceptor 5 isoform A
NM_175080.3 NP_778255.1 P2X purinoceptor 5 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-gated ion channel activity IDA
IDA: Inferred from direct assay
12761352 GOA
enables ligand-gated monoatomic anion channel activity IDA
IDA: Inferred from direct assay
12761352 GOA
Biological Process GO Annotation Evidence References Source
involved in chloride transport IDA
IDA: Inferred from direct assay
12761352 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
20223879 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX5 Protein Structure

P2X_receptor

P2X_receptor: ATP P2X receptor (14 - 330)

P2X_receptor

P2X_receptor: ATP P2X receptor (328 - 364)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 422 a.a.
Protein Preferred Names Protein Names

P2X purinoceptor 5

  • ATP receptor subunit

Related Diseases

Diseases Alias
Infiltrative Basal Cell Carcinoma

  • Skin Infiltrating Basal Cell Carcinoma
Cystinosis

  • Cystine Storage Disease

  • Cystine Diathesis

  • Cystine Disease

  • Cystinoses

  • Protein Defect Of Cystin Transport

  • Cystin Transport, Protein Defect Of

  • Nephropathic Cystinosis

  • Protein Defect Of Cystine Transport
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09909 P2RX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus P2RX5 RGD RGD:620256
Mus musculus P2RX5 MGD MGI:2137026