Aco1 - aconitase 1 Gene

Also Known as AH; IRP1; Acon1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50655

Summary

This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism [provided by RefSeq, Jan 2014]

Aco1 Products (1)

mRNA Protein Name
NM_017321.2 NP_059017.2 cytoplasmic aconitate hydratase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
1527027 RGD
enables aconitate hydratase activity IDA
IDA: Inferred from direct assay
9092825 RGD
enables iron-responsive element binding IDA
IDA: Inferred from direct assay
9092825 RGD
enables iron-sulfur cluster binding IDA
IDA: Inferred from direct assay
9092825 RGD
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
9092825 RGD
Biological Process GO Annotation Evidence References Source
involved in intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
15086359 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
755797 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16144863 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic aconitate hydratase

  • IRE-BP 1

  • aconitase 1, soluble

  • citrate hydro-lyase

  • iron regulatory protein 1

  • iron-responsive element-binding protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00170 ACO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18459 Aco1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24940 Aco1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aco1 NCBI NCBI:48