L1cam - L1 cell adhesion molecule Gene

Also Known as Hyd; Hsas; NgCAM; NCAML1; N-CAM L1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50687

Summary

Enables PDZ domain binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and generation of neurons. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Is active in Schaffer collateral - CA1 synapse. Used to study hydrocephalus. Biomarker of anxiety disorder; hypothyroidism; and mental depression. Human ortholog(s) of this gene implicated in MASA syndrome; hydrocephalus; ovarian carcinoma; pancreatic cancer; and schizophrenia. Orthologous to human L1CAM (L1 cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

L1cam Products (1)

mRNA Protein Name
NM_017345.2 NP_059041.2 neural cell adhesion molecule L1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
11152476 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
18519736 RGD
Biological Process GO Annotation Evidence References Source
involved in axonal fasciculation IMP
IMP: Inferred from mutant phenotype
3856258 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
1377284 RGD
NOT involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
18926887 RGD
involved in cellular response to ethanol IEP
IEP: Inferred from expression pattern
21884525 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
3511068 RGD
involved in cellular response to thyroxine stimulus IEP
IEP: Inferred from expression pattern
11085884 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
16686695 RGD
involved in cerebellar neuron development IMP
IMP: Inferred from mutant phenotype
27027721 RGD
involved in dopaminergic neuron differentiation IEP
IEP: Inferred from expression pattern
1350253 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
7997264 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
7997264 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
24841827 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
18519736 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
8636223 RGD
involved in protein localization to plasma membrane raft IDA
IDA: Inferred from direct assay
27027721 RGD
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16478533 RGD
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
27027721 RGD
involved in regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
27027721 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
12499861 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
11085884 RGD
involved in response to toluene IDA
IDA: Inferred from direct assay
27027721 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
7997264 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
7997264 RGD
located in axon IDA
IDA: Inferred from direct assay
18299352 RGD
located in axonal growth cone IDA
IDA: Inferred from direct assay
15355311 RGD
located in cell surface IDA
IDA: Inferred from direct assay
18299352 RGD
located in dendrite IDA
IDA: Inferred from direct assay
18299352 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
15355311 RGD
located in endosome IDA
IDA: Inferred from direct assay
18299352 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18299352 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neural cell adhesion molecule L1

  • N-CAM-L1

  • NCAM-L1

  • NILE

  • nerve-growth factor-inducible large external glycoprotein

  • neuron-glia cell adhesion molecule

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184514 TPA(bi(Tos))-γ-Glu(PEG23)-Glu-Val-Cit-PAB-PNU-159682 / Unkown
HY-184522 TPA(bi(Tos))-γ-Glu(PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 / Unkown
HY-RS07481 L1CAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18070 L1cam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24545 L1cam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992253 Anti-L1-CAM Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens L1cam NCBI NCBI:3897