Spast - spastin Gene

Also Known as Spg4; mKIAA1083

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50850

Summary

Predicted to enable microtubule-severing ATPase activity and tubulin binding activity. Involved in anterograde axonal transport and axonal transport of mitochondrion. Acts upstream of or within microtubule severing. Located in microtubule Cytoskeleton and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study hereditary spastic paraplegia 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin). [provided by Alliance of Genome Resources, Apr 2022]

Spast Products (4)

mRNA Protein Name
NM_001162870.2 NP_001156342.1 spastin isoform 1
NM_001357738.2 NP_001344667.1 spastin isoform 3
NM_001414036.1 NP_001400965.1 spastin isoform 4
NM_016962.3 NP_058658.2 spastin isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal transport IMP
IMP: Inferred from mutant phenotype
19453301 MGI
involved in axonal transport of mitochondrion IMP
IMP: Inferred from mutant phenotype
19453301 MGI
acts upstream of or within microtubule severing IDA
IDA: Inferred from direct assay
20530212 MGI
acts upstream of or within microtubule severing IGI
IGI: Inferred from genetic interaction
20530212 MGI
acts upstream of or within microtubule severing IMP
IMP: Inferred from mutant phenotype
20530212 MGI
Cellular Component GO Annotation Evidence References Source
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
20530212 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12490534 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spastin

  • spastic paraplegia 4 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13634 SPAST Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19038 Spast Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25527 Spast Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spast NCBI NCBI:6683