A4GNT - alpha-1,4-N-acetylglucosaminyltransferase Gene

Also Known as alpha4GnT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51146

About A4GNT

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,123,713-138,133,302 (from NCBI)

This gene has 1 transcript (splice variant), 169 orthologues and 1 paralogue. Biased expression in stomach (RPKM 9.5), duodenum (RPKM 0.9) and 1 other tissue.

Summary

This gene encodes a protein from the Glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]

A4GNT Products (1)

mRNA Protein Name
NM_016161.3 NP_057245.1 alpha-1,4-N-acetylglucosaminyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
10430883 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within glycoprotein biosynthetic process IDA
IDA: Inferred from direct assay
10430883 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

A4GNT Protein Structure

Gly_transf_sug

Gly_transf_sug: Glycosyltransferase sugar-binding region containing DXD motif (64 - 179)

Gb3_synth

Gb3_synth: Alpha 1,4-glycosyltransferase conserved region (196 - 323)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

alpha-1,4-N-acetylglucosaminyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70140 α-1,4-N-Acetylglucosaminyltransferase 4 Inhibitor / Unkown
HY-RS00014 A4GNT Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta A4GNT VGNC VGNC:81171
Bos taurus A4GNT VGNC VGNC:25436
Felis catus A4GNT VGNC VGNC:59446
Rattus norvegicus A4GNT RGD RGD:1590210
Canis familiaris A4GNT VGNC VGNC:37401
Mus musculus A4GNT MGD MGI:2143261
Others A4GNT NCBI