CPA4 - carboxypeptidase A4 Gene

Also Known as CPA3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51200

About CPA4

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,293,161-130,324,180 (from NCBI)

This gene has 11 transcripts (splice variants), 126 orthologues and 8 paralogues. Biased expression in skin (RPKM 24.3) and esophagus (RPKM 4.3).

Summary

This gene is a member of the Carboxypeptidase A/B subfamily, and it is located in a cluster with three Other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal Amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate Cancer aggressiveness. [provided by RefSeq, Jul 2008]

CPA4 Products (2)

mRNA Protein Name
NM_001163446.2 NP_001156918.1 carboxypeptidase A4 isoform 2 precursor
NM_016352.4 NP_057436.2 carboxypeptidase A4 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metallocarboxypeptidase activity IDA
IDA: Inferred from direct assay
20385563 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23746805 GOA
Biological Process GO Annotation Evidence References Source
involved in hormone catabolic process IDA
IDA: Inferred from direct assay
20385563 GOA
involved in peptide catabolic process IDA
IDA: Inferred from direct assay
20385563 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20385563 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPA4 Protein Structure

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (27 - 102)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (131 - 407)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

carboxypeptidase A4

  • carboxypeptidase A3

Related Diseases

Diseases Alias
Thiopental Allergy

  • Penthiobarbital Allergy

  • Pentothiobarbital Allergy
Esophagitis, Eosinophilic, 1

  • Eosinophilic Esophagitis

  • EOE1

  • Esophagitis, Eosinophilic

  • Ee
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184654 MR-39 / Unkown
HY-RS03083 CPA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19589 Cpa4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26086 Cpa4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPA4 VGNC VGNC:61114
Bos taurus CPA4 VGNC VGNC:107220
Mus musculus CPA4 MGD MGI:1919041
Macaca mulatta CPA4 VGNC VGNC:71411
Canis familiaris CPA4 VGNC VGNC:39545
Rattus norvegicus CPA4 RGD RGD:1563619
Others CPA4 NCBI