WNT16 - Wnt family member 16 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51384

About WNT16

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:121,325,367-121,341,104 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 18 paralogues. Biased expression in skin (RPKM 9.9) and lymph node (RPKM 0.5).

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

WNT16 Products (2)

mRNA Protein Name
NM_016087.2 NP_057171.2 protein Wnt-16 isoform 2
NM_057168.2 NP_476509.1 protein Wnt-16 isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19951988 GOA
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
17200136 GOA
involved in keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
17200136 GOA
involved in negative regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
17200136 GOA
involved in oxidative stress-induced premature senescence IMP
IMP: Inferred from mutant phenotype
19951988 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
17200136 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16007226 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
19951988 GOA
involved in replicative senescence IMP
IMP: Inferred from mutant phenotype
19951988 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17200136 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
10500199 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT16 Protein Structure

wnt

wnt: wnt family (51 - 365)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

protein Wnt-16

  • wingless-type MMTV integration site family member 16b

WNT16 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82676 Wnt16 Antibody (YA2421) WB, IP Human, Mouse, Rat
HY-P82676A Wnt16 Antibody (YA2421)(PBS only) WB, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Osteoporosis-Pseudoglioma Syndrome

  • OPPG

  • Ops

  • Osteoporosis With Pseudoglioma

  • Osteogenesis Imperfecta, Ocular Form

  • Ocular Form Of Osteogenesis Imperfecta

  • Osteogenesis Imperfecta Ocular Form

  • Osteoporosis Pseudoglioma Syndrome

  • Pseudoglioma With Bone Fragility
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Van Buchem Disease

  • Hyperostosis Corticalis Generalisata

  • Hyperphosphatasemia Tarda

  • VBCH

  • Sost-Related Sclerosing Bone Dysplasia

  • Endosteal Hyperostosis Autosomal Recessive

  • Sclerosteosis

  • Endosteal Hyperostosis, Autosomal Recessive

  • Hyperotosis Corticalis Generalisata Familiaris

  • Sost Sclerosing Bone Dysplasia

  • Smith-Lemli-Opitz Syndrome
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Sclerosteosis

  • Cortical Hyperostosis With Syndactyly

  • Sost

  • Cortical Hyperostosis-Syndactyly Syndrome
Norrie Disease

  • Atrophia Bulborum Hereditaria

  • Episkopi Blindness

  • Pseudoglioma

  • ND

  • Norrie-Warburg Disease

  • Anderson-Warburg Syndrome

  • Fetal Iritis Syndrome

  • Norrie Syndrome

  • Norrie-Warburg Syndrome

  • Ndp

  • Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

  • Norrie'S Disease

  • Oligophrenia Microphthalmus

  • Pseudoglioma Congenita

  • Whitnall-Norman Syndrome
Exudative Vitreoretinopathy

  • Familial Exudative Vitreoretinopathy

  • Fevr

  • Criswick-Schepens Syndrome

  • Exudative Vitreoretinopathy, Familial

  • Vitreoretinopathy, Exudative )

  • Exudative Vitreoretinopathy 1
Scoliosis
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Brittle Bone Disorder

  • Osteogenesis Imperfecta

  • Brittle Bone Disease

  • Fragilitas Ossium

  • Osteopsathyrosis

  • Lobstein Disease

  • Oi

  • Vrolik Disease

  • Lobstein'S Disease

  • Lobstein'S Syndrome

  • Vrolik'S Disease

  • Porak And Durante Disease

  • Glass Bone Disease

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal

  • Osteogenesis Imperfecta, Recessive Perinatal Lethal

  • Brittle Bone Syndrome

  • Oi - [Osteogenesis Imperfecta]

  • Ossium Fragility

  • Osteitis Fragilitans

  • Bony Fragility

  • Blue Sclera With Fragility Of Bone And Deafness

  • White Blue Sclera - Fragility Of Bone - Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15831 WNT16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19755 Wnt16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26252 Wnt16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus WNT16 VGNC VGNC:67083
Rattus norvegicus WNT16 RGD RGD:1562253
Bos taurus WNT16 VGNC VGNC:36956
Macaca mulatta WNT16 VGNC VGNC:79020
Canis familiaris WNT16 VGNC VGNC:49699
Mus musculus WNT16 MGD MGI:2136018
Others WNT16 NCBI