PPME1 - protein phosphatase methylesterase 1 Gene

Also Known as PME-1; ABDH19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51400

About PPME1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,171,289-74,254,703 (from NCBI)

This gene has 9 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a protein Phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

PPME1 Products (2)

mRNA Protein Name
NM_001271593.2 NP_001258522.1 protein phosphatase methylesterase 1 isoform b
NM_016147.3 NP_057231.1 protein phosphatase methylesterase 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein C-terminal methylesterase activity IDA
IDA: Inferred from direct assay
10318862 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22167190 GOA
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
10318862 GOA
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
10318862 GOA
Biological Process GO Annotation Evidence References Source
involved in protein demethylation IDA
IDA: Inferred from direct assay
10318862 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPME1 Protein Structure

Abhydrolase_6

Abhydrolase_6: Alpha/beta hydrolase family (79 - 362)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

protein phosphatase methylesterase 1

  • testicular secretory protein Li 39

Related Diseases

Diseases Alias
Alzheimer Disease 15

  • AD15

  • Alzheimer'S Disease 15

  • Alzheimer Disease Without Neurofibrillary Tangles

  • Alzheimer'S Disease 15, Late Onset

  • Alzheimer'S Disease Without Neurofibrillary Tangles
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10971 PPME1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPME1 RGD RGD:1309683
Macaca mulatta PPME1 VGNC VGNC:76345
Mus musculus PPME1 MGD MGI:1919840
Felis catus PPME1 VGNC VGNC:64316
Canis familiaris PPME1 VGNC VGNC:44873
Bos taurus PPME1 VGNC VGNC:33218
Others PPME1 NCBI