ANAPC7 - anaphase promoting complex subunit 7 Gene
Also Known as APC7; FERBON
Species: Homo sapiens
About ANAPC7
This gene has 12 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), esophagus (RPKM 9.0) and 25 other tissues.
Summary
This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin Ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
ANAPC7 Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_001137664.2 | NP_001131136.2 | anaphase-promoting complex subunit 7 isoform b |
| NM_001385208.1 | NP_001372137.1 | anaphase-promoting complex subunit 7 isoform c precursor |
| NM_001385209.1 | NP_001372138.1 | anaphase-promoting complex subunit 7 isoform d |
| NM_001385210.1 | NP_001372139.1 | anaphase-promoting complex subunit 7 isoform d |
| NM_001385211.1 | NP_001372140.1 | anaphase-promoting complex subunit 7 isoform e |
| NM_001385212.1 | NP_001372141.1 | anaphase-promoting complex subunit 7 isoform f |
| NM_016238.3 | NP_057322.3 | anaphase-promoting complex subunit 7 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables enzyme-substrate adaptor activity |
IDA
IDA: Inferred from direct assay
|
34942119 | GOA |
| enables protein phosphatase binding |
IPI
IPI: Inferred from physical interaction
|
21241890 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in anaphase-promoting complex-dependent catabolic process |
IDA
IDA: Inferred from direct assay
|
29033132 | GOA |
| involved in brain development |
IMP
IMP: Inferred from mutant phenotype
|
34942119 | GOA |
| involved in protein K11-linked ubiquitination |
IDA
IDA: Inferred from direct assay
|
18485873 | GOA |
| involved in protein K48-linked ubiquitination |
IDA
IDA: Inferred from direct assay
|
29033132 | GOA |
| involved in protein branched polyubiquitination |
IDA
IDA: Inferred from direct assay
|
29033132 | GOA |
| involved in protein ubiquitination |
IMP
IMP: Inferred from mutant phenotype
|
34942119 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of anaphase-promoting complex |
IDA
IDA: Inferred from direct assay
|
16364912 | GOA |
| part of anaphase-promoting complex |
IPI
IPI: Inferred from physical interaction
|
27120157 | GOA |
| located in heterochromatin |
IMP
IMP: Inferred from mutant phenotype
|
34942119 | GOA |
| located in microtubule cytoskeleton |
IDA
IDA: Inferred from direct assay
|
18445686 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
18445686 | GOA |
| located in spindle |
IDA
IDA: Inferred from direct assay
|
18445686 | GOA |
ANAPC7 Protein Structure
TPR_11: TPR repeat (345 - 404)
TPR_2: Tetratricopeptide repeat (512 - 542)
- 0
- 100
- 200
- 300
- 400
- 500
- 599 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
anaphase-promoting complex subunit 7 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ferguson-Bonni Neurodevelopmental Syndrome |
|
|
| B-Lymphoblastic Leukemia/Lymphoma With Tcf3-Pbx1 |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS00683 | ANAPC7 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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