2. Gene
  3. ANAPC7 - anaphase promoting complex subunit 7 Gene

ANAPC7 - anaphase promoting complex subunit 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APC7; FERBON

Gene ID: 51434 | Gene type: protein coding

About ANAPC7

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,372,900-110,403,708 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), esophagus (RPKM 9.0) and 25 other tissues.

Summary

This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

ANAPC7 Products(7)

mRNA Protein Name
NM_001137664.2 NP_001131136.2 anaphase-promoting complex subunit 7 isoform b
NM_001385208.1 NP_001372137.1 anaphase-promoting complex subunit 7 isoform c precursor
NM_001385209.1 NP_001372138.1 anaphase-promoting complex subunit 7 isoform d
NM_001385210.1 NP_001372139.1 anaphase-promoting complex subunit 7 isoform d
NM_001385211.1 NP_001372140.1 anaphase-promoting complex subunit 7 isoform e
NM_001385212.1 NP_001372141.1 anaphase-promoting complex subunit 7 isoform f
NM_016238.3 NP_057322.3 anaphase-promoting complex subunit 7 isoform a

ANAPC7 Protein Structure

TPR_11

TPR_11: TPR repeat (345 - 404)

TPR_2

TPR_2: Tetratricopeptide repeat (512 - 542)

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  • 500
  • 599 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit 7

cyclosome subunit 7

Related Diseases

Diseases Alias
Ferguson-Bonni Neurodevelopmental Syndrome

FERBON
B-Lymphoblastic Leukemia/Lymphoma With Tcf3-Pbx1

B Acute Lymphoblastic Leukemia With T(1

19)(Q23

P13.3)

E2a-Pbx1 (Tcf3-Pbx1)

B-All With Tcf3-Pbx1

B-Lymphoblastic Leukemia/Lymphoma With T(1

19)(Q23

P13.3)

Tcf3-Pbx1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00683 ANAPC7 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ANAPC7 VGNC VGNC:59777
Macaca mulatta ANAPC7 VGNC VGNC:108286
Mus musculus ANAPC7 MGD MGI:1929711
Canis familiaris ANAPC7 VGNC VGNC:52919
Rattus norvegicus ANAPC7 RGD RGD:1311927
Bos taurus ANAPC7 VGNC VGNC:53888