Rif1 - replication timing regulatory factor 1 Gene

Also Known as D2Ertd145e; 5730435J01Rik; 6530403D07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 51869

Summary

Involved in positive regulation of histone H3-K9 methylation; regulation of nucleobase-containing compound metabolic process; and telomere organization. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and stem cell population maintenance. Located in chromosome and pronucleus. Is expressed in several structures, including early conceptus; hindgut epithelium; primordial germ cell; reproductive system; and urinary system. Orthologous to human RIF1 (replication timing regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Rif1 Products (3)

mRNA	Protein	Name
NM_001355414.1	NP_001342343.1	telomere-associated protein RIF1 isoform a
NM_001355415.1	NP_001342344.1	telomere-associated protein RIF1 isoform b
NM_175238.6	NP_780447.4	telomere-associated protein RIF1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17093407	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in negative regulation of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	23306437	MGI
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	24735877	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24735877	MGI
involved in positive regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	23306437	MGI
involved in positive regulation of isotype switching	IMP IMP: Inferred from mutant phenotype	23306439	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16518401	MGI
involved in subtelomeric heterochromatin formation	IMP IMP: Inferred from mutant phenotype	24735877	MGI
involved in telomere maintenance	IMP IMP: Inferred from mutant phenotype	24735877	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IMP IMP: Inferred from mutant phenotype	24735877	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	15042697	MGI
is active in chromosome, telomeric repeat region	IDA IDA: Inferred from direct assay	24735877	MGI
located in female pronucleus	IDA IDA: Inferred from direct assay	15042697	MGI
located in male pronucleus	IDA IDA: Inferred from direct assay	15042697	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15042697	MGI
located in site of double-strand break	IDA IDA: Inferred from direct assay	23306437	MGI
located in site of double-strand break	IMP IMP: Inferred from mutant phenotype	23333305	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
telomere-associated protein RIF1	Rap1 interacting factor 1 homolog mRif1 rap1-interacting factor 1 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11971	RIF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06843	INSL6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07786	LRIF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19378	Rif1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20965	Insl6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25870	Rif1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rif1	NCBI	NCBI:55183