Dlg3 - discs large MAGUK scaffold protein 3 Gene

Also Known as Dlgh3; SAP102; mKIAA1232

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53310

Summary

Enables ubiquitin protein Ligase binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within establishment of planar polarity and establishment or maintenance of epithelial cell apical/basal polarity. Located in several cellular components, including bicellular tight junction; glutamatergic synapse; and plasma membrane. Part of AMPA glutamate receptor complex. Is expressed in central nervous system and retina. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dlg3 Products (5)

mRNA Protein Name
NM_001177778.2 NP_001171249.1 disks large homolog 3 isoform 2
NM_001177779.1 NP_001171250.1 disks large homolog 3 isoform 3
NM_001177780.1 NP_001171251.1 disks large homolog 3 isoform 4
NM_001290402.1 NP_001277331.1 disks large homolog 3 isoform 5
NM_016747.4 NP_058027.1 disks large homolog 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12351654 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21920314 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
21920314 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
21920314 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: Inferred from direct assay
17046693 MGI
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: Inferred from mutant phenotype
17046693 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
21920314 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
21920314 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12351654 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17046693 MGI
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
25429150 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17046693 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21920314 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 3

  • discs, large homolog 3

  • synapse-associated protein 102

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03798 DLG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08624 MPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20714 Dlg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27225 Dlg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg3 NCBI NCBI:1741