ATAD2B - ATPase family AAA domain containing 2B Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54454

About ATAD2B

Cytogenetic location: 2p24.1-p23.3 Genomic coordinates (GRCh38): 2:23,677,969-23,927,123 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 1.9), testis (RPKM 1.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ATAD2B Products (3)

mRNA Protein Name
NM_001242338.3 NP_001229267.2 ATPase family AAA domain-containing protein 2B isoform 2
NM_001354107.2 NP_001341036.1 ATPase family AAA domain-containing protein 2B isoform 3
NM_017552.4 NP_060022.2 ATPase family AAA domain-containing protein 2B isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysine-acetylated histone binding IDA
IDA: Inferred from direct assay
22464331 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24561620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATAD2B Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (438 - 571)

Bromodomain

Bromodomain: Bromodomain (972 - 1043)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1458 a.a.
Protein Preferred Names Protein Names

ATPase family AAA domain-containing protein 2B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10326 Z-ATAD-FMK Inhibitor / Unkown
HY-RS01120 ATAD2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATAD2B VGNC VGNC:26234
Canis familiaris ATAD2B VGNC VGNC:38202
Mus musculus ATAD2B MGD MGI:2444798
Felis catus ATAD2B VGNC VGNC:59990
Macaca mulatta ATAD2B VGNC VGNC:106130
Rattus norvegicus ATAD2B RGD RGD:1566199
Others ATAD2B NCBI