ING3 - inhibitor of growth family member 3 Gene

Also Known as Eaf4; ING2; MEAF4; p47ING3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54556

About ING3

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:120,950,777-120,977,216 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 18.3), lymph node (RPKM 6.0) and 24 other tissues.

Summary

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce Apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and Bax. Overexpression of this gene has been shown to inhibit cell growth and induce Apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

ING3 Products (2)

mRNA Protein Name
NM_019071.3 NP_061944.2 inhibitor of growth protein 3 isoform 1
NM_198267.2 NP_938008.1 inhibitor of growth protein 3 isoform 3

ING3 Protein Structure

ING

ING: Inhibitor of growth proteins N-terminal histone-binding (2 - 104)

PHD

PHD: PHD-finger (362 - 408)

  • 0
  • 100
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  • 400
  • 418 a.a.
Protein Preferred Names Protein Names

inhibitor of growth protein 3

Related Diseases

Diseases Alias
Squamous Cell Carcinoma, Head And Neck

  • Squamous Cell Carcinoma Of The Head And Neck

  • HNSCC

  • Head And Neck Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Lip

  • Squamous Cell Carcinoma, Head And Neck, Somatic

  • Carcinoma Of The Head And Neck

  • Squamous Cell Carcinomas Of Head And Neck

  • Scchn

  • Squamous Cell Carcinoma Of The Hypopharynx

  • Squamous Cell Carcinoma Of The Oropharynx

  • Squamous Cell Carcinoma Of Salivary Glands

  • Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

  • Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

  • Squamous Cell Carcinoma Of The Oral Cavity

  • Squamous Cell Carcinoma Of The Lip

  • Carcinoma, Squamous Cell Of Head And Neck

  • Lip Squamous Cell Carcinoma

  • Carcinoma, Squamous Cell, Head And Neck

  • Salivary Gland Squamous Cell Carcinoma

  • Cancer Of Head And Neck

  • Squamous Cell Carcinoma Of Oropharynx Nos
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06809 ING3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ING3 VGNC VGNC:30196
Macaca mulatta ING3 VGNC VGNC:73595
Rattus norvegicus ING3 RGD RGD:1310556
Felis catus ING3 VGNC VGNC:62922
Mus musculus ING3 MGD MGI:1919027
Canis familiaris ING3 VGNC VGNC:42018
Others ING3 NCBI