EPB41L4B - erythrocyte membrane protein band 4.1 like 4B Gene

Also Known as CG1; EHM2; LULU2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54566

About EPB41L4B

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:109,171,974-109,321,059 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 10 paralogues. Broad expression in colon (RPKM 20.8), thyroid (RPKM 15.3) and 18 other tissues.

Summary

Predicted to be a structural constituent of Cytoskeleton. Involved in several processes, including positive regulation of cell adhesion; positive regulation of keratinocyte migration; and wound healing. Acts upstream of or within actomyosin structure organization. Located in apical part of cell; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EPB41L4B Products (3)

mRNA Protein Name
NM_001385623.1 NP_001372552.1 band 4.1-like protein 4B isoform 3
NM_018424.3 NP_060894.2 band 4.1-like protein 4B isoform 1
NM_019114.5 NP_061987.3 band 4.1-like protein 4B isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within actomyosin structure organization IDA
IDA: Inferred from direct assay
22006950 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
23664528 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23664528 GOA
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
23664528 GOA
NOT involved in regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
23664528 GOA
involved in wound healing IDA
IDA: Inferred from direct assay
23664528 GOA
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
22006950 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23664528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPB41L4B Protein Structure

FERM_N

FERM_N: FERM N-terminal domain (89 - 165)

FERM_M

FERM_M: FERM central domain (169 - 277)

FERM_C

FERM_C: FERM C-terminal PH-like domain (283 - 370)

FA

FA: FERM adjacent (FA) (378 - 421)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 900 a.a.
Protein Preferred Names Protein Names

band 4.1-like protein 4B

  • FERM-containing protein CG1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04415 EPB41L4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EPB41L4B VGNC VGNC:28524
Felis catus EPB41L4B VGNC VGNC:61896
Mus musculus EPB41L4B MGD MGI:1859149
Canis familiaris EPB41L4B VGNC VGNC:40397
Macaca mulatta EPB41L4B VGNC VGNC:103260
Rattus norvegicus EPB41L4B RGD RGD:1562988
Others EPB41L4B NCBI