POU6F1 - POU class 6 homeobox 1 Gene

Also Known as BRN5; MPOU; TCFB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5463

About POU6F1

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:51,186,936-51,218,062 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 17 paralogues. Ubiquitous expression in brain (RPKM 4.7), ovary (RPKM 3.6) and 23 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin Cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

POU6F1 Products (3)

mRNA Protein Name
NM_001330422.2 NP_001317351.1 POU domain, class 6, transcription factor 1 isoform 2
NM_001351088.2 NP_001338017.1 POU domain, class 6, transcription factor 1 isoform 3
NM_001368008.1 NP_001354937.1 POU domain, class 6, transcription factor 1 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8645295 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8645295 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8645295 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU6F1 Protein Structure

Pou

Pou: Pou domain - N-terminal to homeobox domain (140 - 213)

Homeobox

Homeobox: Homeobox domain (235 - 290)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

POU domain, class 6, transcription factor 1

  • brain-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10912 POU6F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus POU6F1 VGNC VGNC:68970
Bos taurus POU6F1 VGNC VGNC:33180
Macaca mulatta POU6F1 VGNC VGNC:100092
Rattus norvegicus POU6F1 RGD RGD:620615
Canis familiaris POU6F1 VGNC VGNC:58326
Mus musculus POU6F1 MGD MGI:102935
Others POU6F1 NCBI