PPEF2 - protein phosphatase with EF-hand domain 2 Gene

Also Known as PPP7CB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5470

About PPEF2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,859,867-75,902,452 (from NCBI)

This gene has 8 transcripts (splice variants), 289 orthologues and 12 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the serine/threonine protein Phosphatase with EF-hand motif family. The protein contains a protein Phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]

PPEF2 Products (1)

mRNA Protein Name
NM_006239.3 NP_006230.2 serine/threonine-protein phosphatase with EF-hands 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
20674765 GOA
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
20674765 GOA
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
20674765 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12051765 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of MAPK cascade IDA
IDA: Inferred from direct assay
20674765 GOA
involved in negative regulation of peptidyl-threonine phosphorylation IDA
IDA: Inferred from direct assay
20674765 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPEF2 Protein Structure

PPP5

PPP5: PPP5 TPR repeat region (95 - 163)

Metallophos

Metallophos: Calcineurin-like phosphoesterase (174 - 492)

EF-hand_7

EF-hand_7: EF-hand domain pair (657 - 721)

  • 0
  • 200
  • 400
  • 600
  • 753 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase with EF-hands 2

  • protein phosphatase 7, catalytic subunit, beta isozyme

Related Diseases

Diseases Alias
Retinal Degeneration

  • Degeneration Of Retina
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10938 PPEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPEF2 MGD MGI:1342304
Felis catus PPEF2 VGNC VGNC:68982
Bos taurus PPEF2 VGNC VGNC:53771
Macaca mulatta PPEF2 VGNC VGNC:76233
Canis familiaris PPEF2 VGNC VGNC:57408
Rattus norvegicus PPEF2 RGD RGD:1307093
Others PPEF2 NCBI