TENT5C - terminal nucleotidyltransferase 5C Gene

Also Known as FAM46C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54855

About TENT5C

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:117,606,048-117,628,389 (from NCBI)

This gene has 1 transcript (splice variant), 208 orthologues, 3 paralogues and is associated with 69 phenotypes. Broad expression in bone marrow (RPKM 37.0), testis (RPKM 24.1) and 20 other tissues.

Summary

Enables RNA adenylyltransferase activity. Involved in mRNA stabilization. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TENT5C Products (1)

mRNA	Protein	Name
NM_017709.4	NP_060179.2	terminal nucleotidyltransferase 5C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables poly(A) RNA polymerase activity	IDA IDA: Inferred from direct assay	28931820	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA stabilization	IDA IDA: Inferred from direct assay	28931820	GOA
involved in negative regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	32433990	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	32433990	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28931820	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28931820	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENT5C Protein Structure

NTP_transf_7

0
100
200
300
391 a.a.

Protein Preferred Names	Protein Names
terminal nucleotidyltransferase 5C	family with sequence similarity 46 member C

Related Diseases

Diseases	Alias
Smoldering Myeloma
Monoclonal Gammopathy Of Uncertain Significance	Monoclonal Gammopathy Of Undetermined Significance Mgus Mgus - [Monoclonal Gammopathy Of Undetermined Significance] Monoclonal Gammopathy Nos Iga Gammopathy Monoclonal Gammoglobulinopathy
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Plasma Cell Leukemia	Plasma Cell Leukaemia Leukemia, Plasma Cell Plasmacytic Leukaemia Plasmacytic Leukemia Pcl Plasma Cell Leukaemia, Nos Leukemic Plasma Cell Plasma Cell Leukaemia Without Mention Of Remission

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14368	TENT5C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TENT5C	VGNC	VGNC:79450
Felis catus	TENT5C	VGNC	VGNC:66077
Canis familiaris	TENT5C	VGNC	VGNC:40683
Mus musculus	TENT5C	MGD	MGI:1921895
Rattus norvegicus	TENT5C	RGD	RGD:1359446
Bos taurus	TENT5C	VGNC	VGNC:55689