PPM1B - protein phosphatase, Mg2+/Mn2+ dependent 1B Gene

Also Known as PP2CB; PP2CBETA; PP2C-beta; PPC2BETAX; PP2C-beta-X

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5495

About PPM1B

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:44,168,875-44,246,928 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 9.6), brain (RPKM 8.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this Phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

PPM1B Products (4)

mRNA Protein Name
NM_001033557.3 NP_001028729.1 protein phosphatase 1B isoform 5
NM_002706.6 NP_002697.1 protein phosphatase 1B isoform 1
NM_177968.4 NP_808907.1 protein phosphatase 1B isoform 2
NM_177969.4 NP_808908.1 protein phosphatase 1B isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16872604 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
20801214 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18930133 GOA
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
22750291 GOA
involved in negative regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
22750291 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
18930133 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: Inferred from direct assay
20801214 GOA
involved in protein dephosphorylation IMP
IMP: Inferred from mutant phenotype
18930133 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1B Protein Structure

PP2C

PP2C: Protein phosphatase 2C (23 - 288)

PP2C_C

PP2C_C: Protein serine/threonine phosphatase 2C, C-terminal domain (289 - 369)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 479 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1B

  • protein phosphatase 2C-like protein

PPM1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPM1B O75688 ARRB2 Homo sapiens P32121
PLA
25241761
Intra
PPM1B O75688 ARRB1 Homo sapiens P49407
Anti Tag CoIP
17620599
Intra
PPM1B O75688 ISG15 Homo sapiens P05161
Anti Tag CoIP
16872604
Intra
PPM1B O75688 ISG15 Homo sapiens P05161
Anti Bait CoIP
16872604
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotonia-Cystinuria Syndrome

  • Cystinuria With Mitochondrial Disease

  • 2p21 Microdeletion Syndrome

  • HCS

  • Homozygous 2p16 Deletion Syndrome, Formerly

  • 2p21 Deletion Syndrome

  • Del(2)(P21)

  • Monosomy 2p21

  • Atypical Hypotonia-Cystinuria Syndrome

  • Atypical Hcs
Cystinuria

  • CSNU

  • Cystinuria Type B

  • Cystinuria Type A

  • Cystinuria, Type I, Formerly

  • Csnu1, Formerly

  • Cystinuria, Type Ii, Formerly

  • Cystinuria, Type Iii, Formerly

  • Csnu3, Formerly

  • Cystinuria, Type Non-I, Formerly

  • Cystinuria-Lysinuria

  • Cystinuria-Lysinuria Syndrome

  • Csnu1

  • Csnu3

  • Cystinuria 1

  • Cystinuria Type A/B

  • Cystinuria Type I

  • Cystinuria Type Ii

  • Cystinuria Type Iii

  • Cystinuria Type Non-I

  • Cystinuria, Type A/B

  • Cystinuria Type 1

  • Cystinuria - Lysinuria

  • Csnu - [Cystinuria]

  • Cystine Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159521 HN252 Inhibitor 99.94% Unkown
HY-RS10961 PPM1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19472 Ppm1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25965 Ppm1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPM1B VGNC VGNC:68993
Bos taurus PPM1B VGNC VGNC:33209
Mus musculus PPM1B MGD MGI:101841
Macaca mulatta PPM1B VGNC VGNC:76241
Rattus norvegicus PPM1B RGD RGD:3374
Canis familiaris PPM1B VGNC VGNC:44863
Others PPM1B NCBI