NEIL3 - nei like DNA glycosylase 3 Gene

Also Known as FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55247

About NEIL3

Cytogenetic location: 4q34.3 Genomic coordinates (GRCh38): 4:177,309,874-177,371,268 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues.

Summary

NEIL3 belongs to a class of DNA glycosylases homologous to the Bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving Bases damaged by Reactive Oxygen Species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

NEIL3 Products (1)

mRNA Protein Name
NM_018248.3 NP_060718.3 endonuclease 8-like 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
23755964 GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
IDA: Inferred from direct assay
19170771 GOA
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
19170771 GOA
Biological Process GO Annotation Evidence References Source
involved in base-excision repair IDA
IDA: Inferred from direct assay
23755964 GOA
involved in single strand break repair IDA
IDA: Inferred from direct assay
19170771 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12433996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEIL3 Protein Structure

H2TH

H2TH: Formamidopyrimidine-DNA glycosylase H2TH domain (165 - 227)

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (317 - 345)

zf-GRF

zf-GRF: GRF zinc finger (506 - 548)

zf-GRF

zf-GRF: GRF zinc finger (552 - 595)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

endonuclease 8-like 3

  • DNA glycosylase FPG2

NEIL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810988 NEIL3 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09189 NEIL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22676 Neil3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29190 Neil3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NEIL3 VGNC VGNC:31990
Mus musculus NEIL3 MGD MGI:2384588
Macaca mulatta NEIL3 VGNC VGNC:75248
Rattus norvegicus NEIL3 RGD RGD:1310562
Canis familiaris NEIL3 VGNC VGNC:43728
Felis catus NEIL3 VGNC VGNC:63768
Others NEIL3 NCBI