PI4K2B - phosphatidylinositol 4-kinase type 2 beta Gene

Also Known as PIK42B; PI4KIIB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55300

About PI4K2B

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,234,033-25,279,204 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 18.2), small intestine (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with Other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016]

PI4K2B Products (1)

mRNA Protein Name
NM_018323.4 NP_060793.2 phosphatidylinositol 4-kinase type 2-beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: Inferred from direct assay
11923287 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
11923287 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
11923287 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12324459 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
11923287 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12324459 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
12324459 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PI4K2B Protein Structure

PI3_PI4_kinase

PI3_PI4_kinase: Phosphatidylinositol 3- and 4-kinase (131 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 481 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-kinase type 2-beta

  • PI4KII-BETA

Related Diseases

Diseases Alias
Macrocephaly/Autism Syndrome

  • Macrocephaly-Autism Syndrome

  • Macrocephaly-Intellectual Disability-Autism Syndrome

  • MCEPHAS
Developmental And Epileptic Encephalopathy 53

  • DEE53

  • Epileptic Encephalopathy, Early Infantile, 53

  • Eiee53

  • Developmental And Epileptic Encephalopathy, 53

  • Early Infantile Epileptic Encephalopathy 53
Parkinson Disease 20, Early-Onset

  • Early-Onset Parkinson Disease 20

  • PARK20

  • Parkinson'S Disease 20

  • Early-Onset Parkinson'S Disease 20

  • Parkinson Disease, Type 20, Early-Onset
Post-Vaccinal Encephalitis

  • Encephalitis Following Immunization Procedures

  • Postvaccinal Encephalomyelitis

  • Encephalomyelitis, Acute Disseminated
Adams-Oliver Syndrome

  • Adams Oliver Syndrome

  • Aos

  • Congenital Scalp Defects With Distal Limb Reduction Anomalies

  • Aplasia Cutis Congenita With Terminal Transverse Limb Defects

  • Congenital Scalp Defects With Distal Limb Anomalies

  • Limb, Scalp And Skull Defects

  • Limb Scalp And Skull Defects

  • Absence Defect Of Limbs, Scalp, And Skull
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10465 PI4K2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20189 Pi4k2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26693 Pi4k2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PI4K2B VGNC VGNC:110547
Bos taurus PI4K2B VGNC VGNC:97298
Felis catus PI4K2B VGNC VGNC:82521
Mus musculus PI4K2B MGD MGI:1914323
Canis familiaris PI4K2B VGNC VGNC:97213
Rattus norvegicus PI4K2B RGD RGD:1359515
Others PI4K2B NCBI