LSG1 - large 60S subunit nuclear export GTPase 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55341

About LSG1

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,640,791-194,672,191 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 9.7), thyroid (RPKM 9.6) and 25 other tissues.

Summary

This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009]

LSG1 Products (1)

mRNA	Protein	Name
NM_018385.3	NP_060855.2	large subunit GTPase 1 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	16209721	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	16209721	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nuclear export	IDA IDA: Inferred from direct assay	16209721	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	16209721	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16209721	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LSG1 Protein Structure

MMR_HSR1

0
200
400
600
658 a.a.

Protein Preferred Names	Protein Names
large subunit GTPase 1 homolog	hLsg1

Related Diseases

Diseases	Alias
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07851	LSG1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LSG1	VGNC	VGNC:31049
Rattus norvegicus	LSG1	RGD	RGD:1309089
Canis familiaris	LSG1	VGNC	VGNC:42837
Felis catus	LSG1	VGNC	VGNC:63321
Macaca mulatta	LSG1	VGNC	VGNC:74360
Mus musculus	LSG1	MGD	MGI:107236
Others	LSG1	NCBI