Gbp3 - guanylate binding protein 3 Gene

Also Known as Gbp4; GBP-3; GBP-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55932

Summary

Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to Other organism. Located in cytoplasmic vesicle; cytosol; and symbiont-containing vacuole membrane. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Gbp3 Products (4)

mRNA Protein Name
NM_001289492.3 NP_001276421.1 guanylate-binding protein 4
NM_001289493.2 NP_001276422.1 guanylate-binding protein 4
NM_001355403.2 NP_001342332.1 guanylate-binding protein 4
NM_018734.4 NP_061204.3 guanylate-binding protein 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
24739961 MGI
acts upstream of or within adhesion of symbiont to host IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to interferon-beta IDA
IDA: Inferred from direct assay
19158679 MGI
involved in cellular response to interferon-beta IDA
IDA: Inferred from direct assay
18025219 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
24715728 MGI
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
18025219 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: Inferred from direct assay
18025219 MGI
involved in cytolysis in another organism IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
18025219 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
24715728 MGI
acts upstream of or within defense response to protozoan IDA
IDA: Inferred from direct assay
18025219 MGI
involved in positive regulation of pyroptotic inflammatory response IMP
IMP: Inferred from mutant phenotype
24715728 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
18025219 MGI
located in cytosol IDA
IDA: Inferred from direct assay
9659399 MGI
located in symbiont-containing vacuole membrane IDA
IDA: Inferred from direct assay
18025219 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate-binding protein 4

  • GTP-binding protein 3

  • GTP-binding protein 4

  • guanine nucleotide-binding protein 4

  • guanylate nucleotide binding protein 3

  • guanylate nucleotide binding protein 4

  • putative purine nucleotide binding protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01157 ATL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05309 GBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22180 Gbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28702 Gbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gbp3 NCBI NCBI:2635